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Difference between revisions of "Tumour budding"
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'''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | '''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | ||
==Microscopic== | |||
Definitions: | |||
*Tumour bud = 1-4 cell(s). | |||
*"High-grade budding" is >=10 tumour buds in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | |||
Note: | |||
*If the microscope has a 22 mm eye piece and... | |||
**A 20x objective, the field is approximately 0.950 mm<sup>2</sup> -- to match the area/bud -- it would be 24.68 buds/0.950 mm<sup>2</sup>. | |||
**A 40x objective, the field is approximately 0.238 mm<sup>2</sup> -- to match the area/bud -- it would be 6.17 buds/0.238 mm<sup>2</sup>. | |||
===Images=== | |||
<gallery> | |||
Image: Tumour budding in colorectal carcinoma - intermed mag.jpg | Tumour budding in [[CRC]] - intermed. mag. (WC) | |||
Image: Tumour budding in colorectal carcinoma - high mag.jpg | Tumour budding in CRC - high mag. (WC) | |||
Image: Tumour budding in colorectal carcinoma - very high mag.jpg | Tumour budding in CRC - very high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||