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Difference between revisions of "Hepatocellular carcinoma"
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Hepatocellular carcinoma (view source)
Revision as of 01:26, 12 November 2013
, 01:26, 12 November 2013+high-grade dysplasia
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| Micro = architectural changes - liver plate thickness >3 cells thick, +/-nuclear changes of malignancy (very common), variable architecture (pseudoglandular, trabecular, fibrolamellar, solid) | | Micro = architectural changes - liver plate thickness >3 cells thick, +/-nuclear changes of malignancy (very common), variable architecture (pseudoglandular, trabecular, fibrolamellar, solid) | ||
| Subtypes = sclerosing HCC, fibrolamellar HCC | | Subtypes = sclerosing HCC, fibrolamellar HCC | ||
| LMDDx = [[cholangiocarcinoma]], occasionally [[liver metastasis]] | | LMDDx = [[cholangiocarcinoma]], occasionally [[liver metastasis]], [[High-grade hepatocellular dysplasia|high-grade dysplasia]] | ||
| Stains = reticulin (thickened liver plate) | | Stains = reticulin (thickened liver plate) | ||
| IHC = CD34 +ve sinusoids, HepPar-1 +ve (usu.), AFP +ve (usu.), CK8/18 +ve, glypican-3 +ve | | IHC = CD34 +ve sinusoids, HepPar-1 +ve (usu.), AFP +ve (usu.), CK8/18 +ve, glypican-3 +ve | ||
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*[[Cholangiocarcinoma]]. | *[[Cholangiocarcinoma]]. | ||
*Combined HCC-CC.<ref name=pmid21559202>{{Cite journal | last1 = Walther | first1 = Z. | last2 = Jain | first2 = D. | title = Molecular pathology of hepatic neoplasms: classification and clinical significance. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 403929 | month = | year = 2011 | doi = 10.4061/2011/403929 | PMID = 21559202 | PMC = 3090128 }}</ref> | *Combined HCC-CC.<ref name=pmid21559202>{{Cite journal | last1 = Walther | first1 = Z. | last2 = Jain | first2 = D. | title = Molecular pathology of hepatic neoplasms: classification and clinical significance. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 403929 | month = | year = 2011 | doi = 10.4061/2011/403929 | PMID = 21559202 | PMC = 3090128 }}</ref> | ||
*[[High-grade hepatocellular dysplasia|high-grade dysplasia]]. | |||
===Images=== | ===Images=== | ||