Difference between revisions of "Course:Introduction to Neuropathology"

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File:Neuropathology case IX.jpg | [[ATRX]]

File:Neuroparthology case IX 0125.jpg | [[IDH1]]

File:Neuroparthology case IX 0125.jpg | panCK

</gallery>

[[Glioblastoma]] is a pleomorphic astroglial tumor with endothelial proliferations and necrosis. As expected by a malignant tumor, the number of proliferating cells (MIB-1) is high. The tumour cells often stain for GFAP. There is no ATRX loss and the IDH1 R132H mutation is absent (negative staining).

{{hidden|Other language: German| Glioblastome sind pleomorphe astrogliale Tumore mit Gefäßproliferaten und Nekrosen. Entsprechend einem malignen Tumor ist die Anzahl der proliferierenden Zellen (MIB-1) hoch. Die Tumorzellen markieren sich für GFAP. Es besteht kein Verlust von ATRX und die IDH1 R132H Mutationsfärbung ist negativ.

}}

File:Oligodendroglioma1 low mag.jpg | [[H&E]]

File: x | GFAP

File:Neuropathology case II 04.jpg | MIB-1

File:Neuroparthology case IX 0125.jpg | ATRX

File:IDH1 R132H in anaplastic ologodendroglioma.jpg | [[IDH1]]

File:Neuropathology case IX.jpg | panCK

</gallery>

[[Oligodendroglioma]] is a diffuse geowing glial tumour with clear cell morphology. In WHO grade II the MIB-1 proliferation index is rather low. GFAP stains the neuropil background and minigemistocytes (if present). There is no ATRX loss. The vast majority of oligodendrogliomas stain positively for IDH1 R132H mutation.

Difference between revisions of "Course:Introduction to Neuropathology"

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@@ Line 214: / Line 214: @@
 File:Neuropathology case IX.jpg | [[ATRX]]
 File:Neuroparthology case IX 0125.jpg | [[IDH1]]
+File:Neuroparthology case IX 0125.jpg | panCK
 </gallery>
 [[Glioblastoma]] is a pleomorphic astroglial tumor with endothelial proliferations and necrosis. As expected by a malignant tumor, the number of proliferating cells (MIB-1) is high. The tumour cells often stain for GFAP. There is no ATRX loss and the IDH1 R132H mutation is absent (negative staining).
+{{hidden|Other language: German| Glioblastome sind pleomorphe astrogliale Tumore mit Gefäßproliferaten und Nekrosen. Entsprechend einem malignen Tumor ist die Anzahl der proliferierenden Zellen (MIB-1) hoch. Die Tumorzellen markieren sich für GFAP. Es besteht kein Verlust von ATRX und die IDH1 R132H Mutationsfärbung ist negativ.
+}}
+<gallery>
+File:Oligodendroglioma1 low mag.jpg | [[H&E]]
+File: x | GFAP
+File:Neuropathology case II 04.jpg | MIB-1
+File:Neuroparthology case IX 0125.jpg | ATRX
+File:IDH1 R132H in anaplastic ologodendroglioma.jpg | [[IDH1]]
+File:Neuropathology case IX.jpg | panCK
+</gallery>
+[[Oligodendroglioma]] is a diffuse geowing glial tumour with clear cell morphology. In WHO grade II the MIB-1 proliferation index is rather low. GFAP stains the neuropil background and minigemistocytes (if present). There is no ATRX loss. The vast majority of oligodendrogliomas stain positively for IDH1 R132H mutation.