Difference between revisions of "Breast pathology"

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==Mammary myofibroblastoma==
==Mammary myofibroblastoma==
===General===
{{Main|Mammary myofibroblastoma}}
*Rare.
*Excision = cure.
*Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal  | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month =  | year =  | doi =  | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 |    PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/?tool=pubmed}}</ref>
 
Note:
*In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal  | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi =  | PMID = 11474286 }}</ref>
 
===Microscopic===
Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref>
*Well-circumscribed lesion.
*Spindle cells without nuclear atypia arranged in fascicles.
*Interspersed thick bundles of collagen.
 
Notes:
*No calcifications.
*No necrosis.
*No hemorrhage.
 
DDx:
*[[Metaplastic breast carcinoma]].
*Fibromatosis.
*[[Leiomyoma]] of the breast.
*[[Nodular fasciitis]].
*[[Phyllodes tumour]].
 
====Images====
<gallery>
Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)].
 
===IHC===
Features:<ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 }}</ref>
*CD34 +ve.<ref name=pmid11474286/>
*Desmin +ve.<ref name=pmid11474286/>
*H-caldesmon +ve.
*Actin +ve.
*Vimentin +ve.
 
Other
*S100 -ve.
*Beta-catenin -ve. (???)


==Squamous metaplasia of lactiferous ducts==
==Squamous metaplasia of lactiferous ducts==
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