Difference between revisions of "Vermiform appendix"

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*[[Onlinepathology]] prefers the classification of Misdraji,<ref name=pmid12883241>{{cite journal |author=Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH |title=Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases |journal=Am. J. Surg. Pathol. |volume=27 |issue=8 |pages=1089–103 |year=2003 |month=August |pmid=12883241 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=27&issue=8&spage=1089}}</ref> as it is the least complicated
*[[Onlinepathology]] prefers the classification of Misdraji,<ref name=pmid12883241>{{cite journal |author=Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH |title=Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases |journal=Am. J. Surg. Pathol. |volume=27 |issue=8 |pages=1089–103 |year=2003 |month=August |pmid=12883241 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=27&issue=8&spage=1089}}</ref> as it is the least complicated


====Misdraji Classification====
====Misdraji classification====
*Benign - ''low grade mucinous tumour''.
*Benign - ''low grade mucinous tumour''.
*Borderline - ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour''.
*Borderline - ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour''.
*Malignant - ''mucinous adenocarcinoma''.
*Malignant - ''mucinous adenocarcinoma''.


Five year survival (in a series of 107 cases):<ref name=pmid12883241/>  
Five year survival (in a series of 107 cases) as per Misdraji classification:<ref name=pmid12883241/>  
{| class="wikitable sortable"  
{| class="wikitable sortable"  
!Tumour  
!Tumour  
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*LAMN extra-appendiceal = low-grade appendiceal mucinous neoplasm with extra-appendiceal spread.
*LAMN extra-appendiceal = low-grade appendiceal mucinous neoplasm with extra-appendiceal spread.
*MACA = mucinous adenocarcinoma of the appendix.
*MACA = mucinous adenocarcinoma of the appendix.
====WHO classification====
WHO classification:
*Adenoma with low-grade dysplasia.
*Adenoma with high-grade dysplasia.
*Low-grade invasive mucinous adenocarcinoma
**Confined to the appendiceal wall.
**Outside of the appendix.
*High-grade invasive mucinous adenocarcinoma.
====Comparison between Misdraji and WHO classification====
Adapted from ''Panarelli and Yantiss'':<ref name=pmid21970481>{{Cite journal  | last1 = Panarelli | first1 = NC. | last2 = Yantiss | first2 = RK. | title = Mucinous neoplasms of the appendix and peritoneum. | journal = Arch Pathol Lab Med | volume = 135 | issue = 10 | pages = 1261-8 | month = Oct | year = 2011 | doi = 10.5858/arpa.2011-0034-RA | PMID = 21970481 }}</ref>
{| class="wikitable sortable"
! Stage
! Cytologic dysplasia
! Misdraji
! WHO
|-
| Confined to the mucosa
| low-grade
| low-grade appendiceal mucinous neoplasm (LAMN)
| mucinous adenoma, negative for high-grade dysplasia
|-
| Confined to the mucosa
| high-grade
| non-invasive mucinous cystadenocarcinoma of the appendix
| mucinous adenoma with high-grade dysplasia
|-
| At least into the submucosa, confined to the appendix
| low-grade
| low-grade appendiceal mucinous neoplasm (LAMN)
| invasive mucinous adenocarcinoma, low-grade
|-
| At least into the submucosa, confined to the appendix
| high-grade
| mucinous adenocarcinoma of the appendix (MACA)
| invasive mucinous adenocarcinoma, high-grade
|-
| Extra-appendiceal spread
| low-grade
| low-grade appendiceal mucinous neoplasm (LAMN)
| invasive mucinous adenocarcinoma, low-grade
|-
| Extra-appendiceal spread
| high-grade
| mucinous adenocarcinoma of the appendix (MACA)
| invasive mucinous adenocarcinoma, high-grade
|}


===Microscopic===
===Microscopic===
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