Difference between revisions of "POEMS syndrome"

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Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal |vauthors=Dispenzieri A |title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=94 |issue=7 |pages=812–827 |date=July 2019 |pmid=31012139 |doi=10.1002/ajh.25495 |url=}}</ref>
Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal |vauthors=Dispenzieri A |title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=94 |issue=7 |pages=812–827 |date=July 2019 |pmid=31012139 |doi=10.1002/ajh.25495 |url=}}</ref>
Mandatory:
''Mandatory:''
1. Polyneuropathy (typically demyelinating)
;1. Polyneuropathy (typically demyelinating)
2. Monoclonal plasma cell proliferation (usually lambda)
;2. Monoclonal plasma cell proliferation (usually lambda)
Major:
''Major:''
3. [[Castleman disease]]
;3. [[Castleman disease]]
4. Sclerotic bone lesions
;4. Sclerotic bone lesions
5. Vascular endothelial growth factor elevation
;5. Vascular endothelial growth factor elevation
Minor:
''Minor:''
6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)
;6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)
7. Extravascular volume overload
;7. Extravascular volume overload
8. Endocrinopathy
;8. Endocrinopathy
9. Sking changes
;9. Sking changes
10. Papilloedema
;10. Papilloedema
11. Thrombocytosis/polycythemia
;11. Thrombocytosis/polycythemia


POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].
POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].
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