Difference between revisions of "Metanephric adenoma"
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'''Metanephric adenoma''' is a benign tumour of the kidney. | |||
It should '''not''' be confused ''[[mesonephric adenoma]]'', another term for ''nephrogenic adenoma''. | |||
This can be remembered as follows ''me'''t'''anephric adenoma is a '''t'''umour''. | |||
==General== | |||
*Benign. | |||
*Afflicts adults and occasionally children. | |||
*May be associated with [[polycythemia]].<ref name=pmid21220212>{{Cite journal | last1 = Le Nué | first1 = R. | last2 = Marcellin | first2 = L. | last3 = Ripepi | first3 = M. | last4 = Henry | first4 = C. | last5 = Kretz | first5 = JM. | last6 = Geiss | first6 = S. | title = Conservative treatment of metanephric adenoma. A case report and review of the literature. | journal = J Pediatr Urol | volume = 7 | issue = 4 | pages = 399-403 | month = Aug | year = 2011 | doi = 10.1016/j.jpurol.2010.09.010 | PMID = 21220212 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | |||
*Small uniform cells with: | |||
**Fine chromatin. | |||
**No apparent [[nucleolus]]. | |||
**A relatively smooth nuclear membrane. | |||
*Variable architecture - may be sheets or ductal. | |||
DDx: | |||
*Epithelioid nephroblastoma ([[Wilms tumour]]) - these typically have: | |||
**Irregular nuclear membrane. | |||
**Nucleoli. | |||
**Mitoses (rare in ''metanephric adenoma''). | |||
*[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Metanephric_adenoma_high_mag.jpg | Metanephric adenoma (WC/Nephron) | |||
Image:Metanephric_adenoma_high_mag_cropped.jpg | Metanephric adenoma - cropped (WC/Nephron) | |||
Image:Metanephric_adenoma_-_intermed_mag.jpg | Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron) | |||
Image:Metanephric_adenoma_-_very_high_mag.jpg | Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)]. | |||
==IHC== | |||
*WT-1 +ve.<ref name=pmid24083046>{{Cite journal | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue = | pages = 675875 | month = | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref> | |||
*CD57 +ve.<ref name=pmid24083046/> | |||
*AMACR -ve.<ref name=pmid24083046/> | |||
==See also== | |||
*[[Kidney tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Kidney tumours]]. | |||
Revision as of 03:14, 22 December 2013
Metanephric adenoma is a benign tumour of the kidney.
It should not be confused mesonephric adenoma, another term for nephrogenic adenoma. This can be remembered as follows metanephric adenoma is a tumour.
General
- Benign.
- Afflicts adults and occasionally children.
- May be associated with polycythemia.[1]
Microscopic
Features:[2]
- Small uniform cells with:
- Fine chromatin.
- No apparent nucleolus.
- A relatively smooth nuclear membrane.
- Variable architecture - may be sheets or ductal.
DDx:
- Epithelioid nephroblastoma (Wilms tumour) - these typically have:
- Irregular nuclear membrane.
- Nucleoli.
- Mitoses (rare in metanephric adenoma).
- Papillary RCC.[2]
Images
Metanephric adenoma (WC/Nephron)
Metanephric adenoma - cropped (WC/Nephron)
Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron)
Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron)
www:
IHC
See also
References
- ↑ Le Nué, R.; Marcellin, L.; Ripepi, M.; Henry, C.; Kretz, JM.; Geiss, S. (Aug 2011). "Conservative treatment of metanephric adenoma. A case report and review of the literature.". J Pediatr Urol 7 (4): 399-403. doi:10.1016/j.jpurol.2010.09.010. PMID 21220212.
- ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 284. ISBN 978-0781765275.
- ↑ 3.0 3.1 3.2 Watanabe, S.; Naganuma, H.; Shimizu, M.; Ota, S.; Murata, S.; Nihei, N.; Matsushima, J.; Mikami, S. et al. (2013). "Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases.". Case Rep Pathol 2013: 675875. doi:10.1155/2013/675875. PMID 24083046.
.