Difference between revisions of "Malakoplakia"

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*[http://commons.wikimedia.org/wiki/File:Michaelis-Gutmann_bodies_-_very_high_mag_-_cropped.jpg Michaelis-Gutmann bodies - high mag. cropped (WC)].
*[http://commons.wikimedia.org/wiki/File:Michaelis-Gutmann_bodies_-_very_high_mag_-_cropped.jpg Michaelis-Gutmann bodies - high mag. cropped (WC)].
*[http://commons.wikimedia.org/wiki/File:Michaelis-Gutmann_bodies_-_very_high_mag.jpg Michaelis-Gutmann bodies - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Michaelis-Gutmann_bodies_-_very_high_mag.jpg Michaelis-Gutmann bodies - high mag. (WC)].
*[http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675(06)70342-4&figureId=fig5&ecomponentId=mmc5 Malakoplakia (pathconsultddx.com)]
*[http://granuloma.homestead.com/malakoplakia_bladder_s92-4486e.jpg Malakoplakia (granuloma.homstead.com)].
*[http://granuloma.homestead.com/malakoplakia_bladder_s92-4486e.jpg Malakoplakia (granuloma.homstead.com)].
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=13&cat3=342&stype=d Michaelis-Gutmann bodies (gfmer.ch)].
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=13&cat3=342&stype=d Michaelis-Gutmann bodies (gfmer.ch)].

Revision as of 21:34, 1 January 2012

Malakoplakia is a thingy that typically arises in the bladder.

General

Gross

  • Yellow mass.[2]
    • May mimic renal cell carcinoma.

Microscopic

Features:[3]

  • Basophilic calcified lysosomes (Michaelis-Gutmann bodies) -- key feature.
    • May be inside or outside of macrophages - often size of RBC or larger.
  • Large foamy macrophages with granular cytoplasm.
  • Occasional multinucleated giant cell.
  • Lymphocytes.

DDx:

Images:

Stains

See also

References

  1. 1.0 1.1 Yousef, GM.; Naghibi, B.; Hamodat, MM. (Feb 2007). "Malakoplakia outside the urinary tract.". Arch Pathol Lab Med 131 (2): 297-300. doi:10.1043/1543-2165(2007)131[297:MOTUT]2.0.CO;2. PMID 17284117.
  2. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70719-7. Accessed on: 9 September 2010.
  3. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1027. ISBN 0-7216-0187-1.