Difference between revisions of "Ovary"

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===[[IHC]]===
===[[IHC]]===
*[[CK]] +ve, [[calretinin]] +ve.<ref name=pmid16092670/>
*[[CK]] +ve, [[calretinin]] +ve.<ref name=pmid16092670/>
==Pregnancy luteoma==
===General===
*Tumour of pregnancy.
*Benign.
*Regress after pregnancy; thus, conservative management.<ref name=pmid21144088>{{Cite journal  | last1 = Masarie | first1 = K. | last2 = Katz | first2 = V. | last3 = Balderston | first3 = K. | title = Pregnancy luteomas: clinical presentations and management strategies. | journal = Obstet Gynecol Surv | volume = 65 | issue = 9 | pages = 575-82 | month = Sep | year = 2010 | doi = 10.1097/OGX.0b013e3181f8c41d | PMID = 21144088 }}</ref>
===Microscopic===
Features:
*Sheets of cells.
*Cells with eosinophilic cytoplasm, round nuclei and prominent [[nucleoli]].
DDx:
*[[Leydig cell tumour]].


==See also==
==See also==

Revision as of 02:23, 31 January 2012

The ovary has a wealth of pathology. It has benign tumours and malignant ones.

Normal

  • Corpora albicans - pale/white body with lobulated contour.
  • Ovarian follicles.
  • Stroma - hyperchromatic - spindle morphology, whorling.
    • If the cells have a round morphology... think about endometriosis.

Micrograph

Cysts

General:

  • Very common.

Most common:

  • Serous cystadenoma.
    • Usually uniloculated.
    • Morphology: ciliated, columnar.
  • Mucinous cystadenoma.
    • Usually multiloculated.[1]
      • Memory device: multiloculated = mucinous.
  • Endometrioma (see endometriosis).
  • Simple cyst.
  • Cancerous cyst (see ovarian cancer).

Notes

  • Epithelium is often lost in processing - may make interpretation challenging
  • Ovarian surface epithelium (previously call germinal epithelium) - covers the ovary
    • Cuboidal/flat epithelium.[2]
    • Has ovarian stroma underneath.
    • Nobnail morphology (free surface larger than basement membrane surface).[3]

Ovarian surface vs. mesothelium:

Endometriosis

Main article: Endometriosis

Ovarian tumours

Main article: Ovarian tumours

For a very brief overview of gynecologic tumours see: Gynecologic pathology.

Benign mesothelial inclusion cyst

Epidemiology

  • Assoc. with previous surgery.
  • May be found incidentally, e.g. during C-section.

Gross

  • May mimic mucinous tumour - to unexperienced.[4]
  • Thin-wall.[5]
  • Clear/translucent fluid.

Microscopic

Features:

  • Benign mesothelium.
    • Single layer of squamoid or cuboid mesothelial cells.[5]

IHC

Pregnancy luteoma

General

  • Tumour of pregnancy.
  • Benign.
  • Regress after pregnancy; thus, conservative management.[6]

Microscopic

Features:

  • Sheets of cells.
  • Cells with eosinophilic cytoplasm, round nuclei and prominent nucleoli.

DDx:

See also

References

  1. ↑ IAV. 6 February 2009.
  2. ↑ Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC (April 2001). "Ovarian surface epithelium: biology, endocrinology, and pathology". Endocr. Rev. 22 (2): 255–88. PMID 11294827. http://edrv.endojournals.org/cgi/pmidlookup?view=long&pmid=11294827.
  3. ↑ ALS. 5 February 2009.
  4. ↑ GAG 26 Feb 2009.
  5. ↑ 5.0 5.1 5.2 Urbanczyk K, Skotniczny K, Kucinski J, Friediger J (2005). "Mesothelial inclusion cysts (so-called benign cystic mesothelioma)--a clinicopathological analysis of six cases". Pol J Pathol 56 (2): 81-7. PMID 16092670.
  6. ↑ Masarie, K.; Katz, V.; Balderston, K. (Sep 2010). "Pregnancy luteomas: clinical presentations and management strategies.". Obstet Gynecol Surv 65 (9): 575-82. doi:10.1097/OGX.0b013e3181f8c41d. PMID 21144088.
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