Difference between revisions of "Sickle cell disease"
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==Liver== | ==Liver== | ||
{{Main|Liver}} | {{Main|Liver}} | ||
*Cirrhosis and liver failure.<ref name=pmid21445921>{{Cite journal | last1 = Hurtova | first1 = M. | last2 = Bachir | first2 = D. | last3 = Lee | first3 = K. | last4 = Calderaro | first4 = J. | last5 = Decaens | first5 = T. | last6 = Kluger | first6 = MD. | last7 = Zafrani | first7 = ES. | last8 = Cherqui | first8 = D. | last9 = Mallat | first9 = A. | title = Transplantation for liver failure in patients with sickle cell disease: challenging but feasible. | journal = Liver Transpl | volume = 17 | issue = 4 | pages = 381-92 | month = Apr | year = 2011 | doi = 10.1002/lt.22257 | PMID = 21445921 }}</ref> | *[[Cirrhosis]] and liver failure.<ref name=pmid21445921>{{Cite journal | last1 = Hurtova | first1 = M. | last2 = Bachir | first2 = D. | last3 = Lee | first3 = K. | last4 = Calderaro | first4 = J. | last5 = Decaens | first5 = T. | last6 = Kluger | first6 = MD. | last7 = Zafrani | first7 = ES. | last8 = Cherqui | first8 = D. | last9 = Mallat | first9 = A. | title = Transplantation for liver failure in patients with sickle cell disease: challenging but feasible. | journal = Liver Transpl | volume = 17 | issue = 4 | pages = 381-92 | month = Apr | year = 2011 | doi = 10.1002/lt.22257 | PMID = 21445921 }}</ref> | ||
==Spleen== | ==Spleen== | ||
Revision as of 02:04, 20 November 2011
Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.
Liver
Main article: Liver
Spleen
Main article: Spleen
- It may lead to auto infarction - result in hypofunction.
- Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.
Gallbladder
Main article: Gallbladder
- Pigment stones.
Kidney
- Renal medullary carcinoma associated with sickle cell trait (heterozygotes for the sickle cell allele).[2]
See also
References
- ↑ Hurtova, M.; Bachir, D.; Lee, K.; Calderaro, J.; Decaens, T.; Kluger, MD.; Zafrani, ES.; Cherqui, D. et al. (Apr 2011). "Transplantation for liver failure in patients with sickle cell disease: challenging but feasible.". Liver Transpl 17 (4): 381-92. doi:10.1002/lt.22257. PMID 21445921.
- ↑ Davis CJ, Mostofi FK, Sesterhenn IA (January 1995). "Renal medullary carcinoma. The seventh sickle cell nephropathy". Am. J. Surg. Pathol. 19 (1): 1–11. PMID 7528470.