Difference between revisions of "Progressive transformation of germinal centers"
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'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare | '''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | ||
==General== | ==General== | ||
| Line 22: | Line 22: | ||
==See also== | ==See also== | ||
*[[Lymph node pathology]]. | *[[Lymph node pathology]]. | ||
*[[Lymph node]]. | |||
*[[Haematopathology]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|1}} | ||
[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
Revision as of 19:07, 19 July 2011
Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
General
- Benign.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]
Clinical:
- Asymptomatic lymphadenopathy.
Microscopic
Features:
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
- Expanded mantle zone.
Images:
