Difference between revisions of "Papillary renal neoplasm with reverse polarity"
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==Molecular== | ==Molecular== | ||
*[[KRAS]] mutations.<ref name=pmid37797754/> | *[[KRAS]] mutations.<ref name=pmid37797754/> | ||
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<pre> | |||
A. Right Kidney, Tumour, Partial Nephrectomy: | |||
- Papillary renal neoplasm with reverse polarity, see comment. | |||
Comment: | |||
The tumour has a papillary architecture, eosinophilic cytoplasm and reversed nuclear polarity. | |||
It stains as follows: | |||
POSITIVE: CK7 (strong, diffuse), AE1/AE3 (strong, diffuse), GATA3 (moderate, diffuse), AMACR (moderate, diffuse), PAX8 (modreate, diffuse). | |||
NEGATIVE: vimentin (stroma), CD117, CD10. | |||
These tumour are thought to be distinct from papillary RCC.[1][2] Limited data suggests they have an indolent behaviour.[3] | |||
1. Pathol Int. 2024 Apr;74(4):222-226. doi: 10.1111/pin.13417. Epub 2024 Mar 8. | |||
2. Hum Pathol. 2023 Dec:142:1-6. doi: 10.1016/j.humpath.2023.09.011. Epub 2023 Oct 4. | |||
3. Am J Surg Pathol. 2019 Aug;43(8):1099-1111. doi: 10.1097/PAS.0000000000001288. https://pubmed.ncbi.nlm.nih.gov/31135486/ | |||
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==See also== | ==See also== | ||
Revision as of 19:00, 17 June 2024
Papillary renal neoplasm with reverse polarity is a rare renal tumour and evolving entity.[1]
General
- Evolving entity.
- Thought to be distinct from eosinophilic papillary renal cell carcinoma.[2][3]
Micro
Features:[1]
- Branching papillae with:
- Thin fibrovascular cores.
- Cuboidal to columnar lining cells with granular eosinophilic cytoplasm.
- May have occasional cytoplasmic clearing.
- Smooth luminal borders.
- Reverse polarized nuclei (luminal nuclei; nuclei closer to lumen than basement membrane).
- Nucleoli absent or small.
DDx:
IHC
Features:[1]
- CK7 +ve.
- CD10 +ve (all cases).
- GATA3 +ve (all cases).
- Vimentin -ve (all cases).
- CD117 -ve.
- AE1/AE3 +ve.
- EMA +ve.
- L1CAM +ve.
Molecular
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A. Right Kidney, Tumour, Partial Nephrectomy: - Papillary renal neoplasm with reverse polarity, see comment. Comment: The tumour has a papillary architecture, eosinophilic cytoplasm and reversed nuclear polarity. It stains as follows: POSITIVE: CK7 (strong, diffuse), AE1/AE3 (strong, diffuse), GATA3 (moderate, diffuse), AMACR (moderate, diffuse), PAX8 (modreate, diffuse). NEGATIVE: vimentin (stroma), CD117, CD10. These tumour are thought to be distinct from papillary RCC.[1][2] Limited data suggests they have an indolent behaviour.[3] 1. Pathol Int. 2024 Apr;74(4):222-226. doi: 10.1111/pin.13417. Epub 2024 Mar 8. 2. Hum Pathol. 2023 Dec:142:1-6. doi: 10.1016/j.humpath.2023.09.011. Epub 2023 Oct 4. 3. Am J Surg Pathol. 2019 Aug;43(8):1099-1111. doi: 10.1097/PAS.0000000000001288. https://pubmed.ncbi.nlm.nih.gov/31135486/
See also
References
- ↑ 1.0 1.1 1.2 Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ (August 2019). "Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study". Am J Surg Pathol 43 (8): 1099–1111. doi:10.1097/PAS.0000000000001288. PMID 31135486.
- ↑ Castillo VF, Trpkov K, Van der Kwast T, Rotondo F, Hamdani M, Saleeb R (April 2024). "Papillary renal neoplasm with reverse polarity is biologically and clinically distinct from eosinophilic papillary renal cell carcinoma". Pathol Int 74 (4): 222–226. doi:10.1111/pin.13417. PMID 38456605.
- ↑ 3.0 3.1 Kim B, Lee S, Moon KC (December 2023). "Papillary renal neoplasm with reverse polarity: a clinicopathologic study of 43 cases with a focus on the expression of KRAS signaling pathway downstream effectors". Hum Pathol 142: 1–6. doi:10.1016/j.humpath.2023.09.011. PMID 37797754.