Difference between revisions of "Biphasic hyalinizing psammomatous renal cell carcinoma"
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'''Biphasic hyalinizing psammomatous renal cell carcinoma''', abbreviated '''BHP RCC''', is a rare type of [[renal cell carcinoma]] with mutations in neurofibromin 2.<ref name=pmid32217839>{{cite journal |vauthors=Argani P, Reuter VE, Eble JN, Vlatkovic L, Yaskiv O, Swanson D, Dickson BC, Antonescu CR, Matoso A, Gagan J, Palsgrove DN |title=Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations |journal=Am J Surg Pathol |volume=44 |issue=7 |pages=901–916 |date=July 2020 |pmid=32217839 |pmc=7350624 |doi=10.1097/PAS.0000000000001467 |url=}}</ref> | '''Biphasic hyalinizing psammomatous renal cell carcinoma''', abbreviated '''BHP RCC''', is a rare type of [[renal cell carcinoma]] with mutations in neurofibromin 2.<ref name=pmid32217839>{{cite journal |vauthors=Argani P, Reuter VE, Eble JN, Vlatkovic L, Yaskiv O, Swanson D, Dickson BC, Antonescu CR, Matoso A, Gagan J, Palsgrove DN |title=Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations |journal=Am J Surg Pathol |volume=44 |issue=7 |pages=901–916 |date=July 2020 |pmid=32217839 |pmc=7350624 |doi=10.1097/PAS.0000000000001467 |url=}}</ref> | ||
==General== | |||
*Evolving entity. | |||
*Very rare. | |||
*Prevalence: male > female. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 05:12, 13 October 2021
Biphasic hyalinizing psammomatous renal cell carcinoma, abbreviated BHP RCC, is a rare type of renal cell carcinoma with mutations in neurofibromin 2.[1]
General
- Evolving entity.
- Very rare.
- Prevalence: male > female.
Microscopic
Features:[1]
- Biphasic cytomorphology:
- Small cells.
- Large cells.
- Psammoma bodies.
DDx:
IHC
Features:[1]
- HNF-1beta +ve
- PAX8 +ve
- CK7 +ve
- EMA +ve.
- AMACR +ve.
- WT1 -ve
- Melan A -ve.
- HMB-45 -ve.
- GATA3 -ve.
- Chromogranin A -ve.
- Synaptophysin -ve.
- FH normal.
- SDHB normal.
References
- ↑ 1.0 1.1 1.2 "Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations". Am J Surg Pathol 44 (7): 901–916. July 2020. doi:10.1097/PAS.0000000000001467. PMC 7350624. PMID 32217839. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350624/.