Difference between revisions of "Neurocytoma"
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*[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | *[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
**Similar to Homer-Wright rosette. | **Similar to Homer-Wright rosette. | ||
*Monomorphic cells with round nuclei and speckled chromatin. | |||
*Perinuclear clearing. | *Perinuclear clearing. | ||
*Ganglion cell differentiation. | |||
*Well-defined cell borders. | *Well-defined cell borders. | ||
*Hyalinized vessels. | |||
*Necrosis absent. | |||
==IHC== | ==IHC== | ||
Revision as of 12:05, 9 July 2018
Neurocytoma is a rare neuropathology tumour.
General
- Rare.
Microscopic
Features:[1]
- Pineocytomatous/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.[2]
- Similar to Homer-Wright rosette.
- Monomorphic cells with round nuclei and speckled chromatin.
- Perinuclear clearing.
- Ganglion cell differentiation.
- Well-defined cell borders.
- Hyalinized vessels.
- Necrosis absent.
IHC
- MIB-1: Usu. low.
- Synapthophysin +ve.
DDx:
- Oligodendroglioma - do not have the characteristic rosettes.
- Ganglioglioma.
- Ependymoma.
- Pilocytic astrocytoma (with predominantly oligo-like cell component).
- Diffuse leptomeningeal gliomeuronal tumour.
Images
Neurocytoma (H&E: WC, Marvin101).
Nuclear NeuN immunoreactivity (WC, Marvin101):
www:
- Neurocytoma (ouhsc.edu).
- Neurocytoma - several images (upmc.edu).
- Neurocytoma - cerebellar - several images (upmc.edu).
IHC
- Synaptophysin +ve.
- Most glial tumour -ve.[3]
See also
References
- ↑ URL: http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm. Accessed on: 12 October 2011.
- ↑ Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
- ↑ URL: http://path.upmc.edu/cases/case383/dx.html. Accessed on: 15 January 2012.