Difference between revisions of "Pneumocytoma"
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*[[Neuroendocrine tumour]] (carcinoid). | *[[Neuroendocrine tumour]] (carcinoid). | ||
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==IHC== | ==IHC== | ||
Revision as of 15:32, 8 February 2017
Pneumocytoma is a rare lung tumour that is typically benign. It is also known as benign sclerosing pneumocytoma.[1]
It was previously known as sclerosing hemangioma.
General
Epidemiology
- Female in 40s.[4]
- Considered benign; excision is curative.
- Rare case reports of metastases.
Gross
- Peripheral, solitary.
- Well-circumscribed.
Microscopic
Features:[4]
- Mixed cell population.
- Variable architecture:
- Papillary.
- Sclerotic.
- Solid.
- Hemorrhagic.
- +/-Granulomas.
DDx:[5]
- Papillary adenoma.
- Neuroendocrine tumour (carcinoid).
IHC
Features:[6]
Negative stains:[6]
- SMA -ve.
- CEA -ve.
- CD34 -ve.
- S100 -ve.
- Chromogranin A -ve.
Others:[2]
- TTF-1 +ve.
- HNF-3 alpha +ve.
- HNF-3 beta +ve.
See also
References
- ↑ Chan, KW.; Gibbs, AR.; Lo, WS.; Newman, GR. (Jun 1982). "Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).". Thorax 37 (6): 404-12. PMID 6291188.
- ↑ 2.0 2.1 Yamazaki, K. (Jul 2004). "Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins.". Virchows Arch 445 (1): 45-53. doi:10.1007/s00428-004-1023-3. PMID 15138814.
- ↑ 3.0 3.1 Einsfelder, BM.; Müller, KM. (Sep 2005). "["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung]". Pathologe 26 (5): 367-77. doi:10.1007/s00292-005-0751-8. PMID 15731902.
- ↑ 4.0 4.1 Keylock, JB.; Galvin, JR.; Franks, TJ. (May 2009). "Sclerosing hemangioma of the lung.". Arch Pathol Lab Med 133 (5): 820-5. PMID 19415961.
- ↑ URL: http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf. Accessed on: 17 June 2010.
- ↑ 6.0 6.1 Rodriguez-Soto, J.; Colby, TV.; Rouse, RV. (Mar 2000). "A critical examination of the immunophenotype of pulmonary sclerosing hemangioma.". Am J Surg Pathol 24 (3): 442-50. PMID 10716159.
- ↑ Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.