Difference between revisions of "Apocrine metaplasia of the breast"

From Libre Pathology
Jump to navigation Jump to search
Line 24: Line 24:


===Images===
===Images===
====Case====
<gallery>
Image: Apocrine metaplasia -- low mag.jpg | AM - low mag.
Image: Apocrine metaplasia -- intermed mag.jpg | AM - intermed. mag.
Image: Apocrine metaplasia -- high mag.jpg | AM - high mag.
Image: Apocrine metaplasia -- very high mag.jpg | AM - very high mag.
Image: Apocrine metaplasia - alt -- very high mag.jpg | AM - very high mag.
</gallery>
====Others====
<gallery>
<gallery>
Image:Fibrocystic_change_-_very_high_mag.jpg | FCC with apocrine metaplasia (right bottom of image) - high mag. (WC/Nephron).
Image:Fibrocystic_change_-_very_high_mag.jpg | FCC with apocrine metaplasia (right bottom of image) - high mag. (WC/Nephron).

Revision as of 16:44, 2 April 2016

Apocrine metaplasia of the breast, also apocrine metaplasia, is a benign change in the breast without increased risk of malignancy.

General

  • Benign/not significant. Can be considered to be pretty wallpaper in the house of breast pathology.
  • Very common in adults.
  • Apocrine lesions as a group are usually benign, some pre-neoplastic and some malignant.[1]

Etiology

  • Increased number of mitochondria.
    • In other body sites this has different names, e.g. Hurthle cell change (thyroid), oncocytic change (kidney).

Microscopic

Features:

  • Eosinophilic cytoplasm - key feature.
  • Voluminous pink cytoplasm.
  • Apocrine snouts may be present.
    • Small protrusiona at the apical aspect of the cell (composed of cytoplasm and plasma membrane).
  • Central round nucleus
    • Prominent nuclear membrane.
    • Prominent, often single nucleolus.

Note:

  • Apocrine changes, i.e. cytoplasmic eosinophilia, can appear in malignant tumours; eosinophilia doesn't make something benign.

Images

Case

  • AM - low mag.

  • AM - intermed. mag.

  • AM - high mag.

  • AM - very high mag.

  • AM - very high mag.

Others

  • FCC with apocrine metaplasia (right bottom of image) - high mag. (WC/Nephron).

  • Breast - Apocrine Change - high power (SKB)

Sign out

  • Typically not reported.

See also

References

  1. ↑ Wells, CA.; El-Ayat, GA. (Dec 2007). "Non-operative breast pathology: apocrine lesions.". J Clin Pathol 60 (12): 1313-20. doi:10.1136/jcp.2006.040626. PMID 18042688.
Retrieved from "https://librepathology.org/w/index.php?title=Apocrine_metaplasia_of_the_breast&oldid=43528"