Difference between revisions of "Breast calcifications"
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==See also== | ==See also== | ||
*[[Medial calcific sclerosis]]. | *[[Medial calcific sclerosis]]. | ||
*[[ | *[[Calcification]]. | ||
==References== | ==References== | ||
Revision as of 16:10, 2 March 2016
Breast calcifications may be found in benign or malignant breast specimens.
General
- Abnormal breast calcifications are considered a marker of malignancy.
- Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.[1]
- The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective).
Microscopic
Features of calcification:
- Purple globs (with concentric rings) on H&E - represent calcium phosphate.
- Q. How to remember? A. Purple = Phosphate.
- Often in the lumen of a gland, may be in the stroma.
- Calcific material typically has a well-demarcated border +/- "sharp corners".
Note:
- Calcium oxalate is not associated with malignancy[2] - visible with (light) polarization.