Difference between revisions of "Atypical lung carcinoid tumour"
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==General== | ==General== | ||
*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | *Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | ||
Treatment: | |||
*Surgery for diagnosis and treatment. | |||
*Chemotherapy for advanced/metastatic disease.<ref name=pmid25218177>{{Cite journal | last1 = Chong | first1 = CR. | last2 = Wirth | first2 = LJ. | last3 = Nishino | first3 = M. | last4 = Chen | first4 = AB. | last5 = Sholl | first5 = LM. | last6 = Kulke | first6 = MH. | last7 = McNamee | first7 = CJ. | last8 = Jänne | first8 = PA. | last9 = Johnson | first9 = BE. | title = Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. | journal = Lung Cancer | volume = 86 | issue = 2 | pages = 241-6 | month = Nov | year = 2014 | doi = 10.1016/j.lungcan.2014.08.012 | PMID = 25218177 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 04:31, 23 December 2015
| Atypical lung carcinoid tumour | |
|---|---|
| Diagnosis in short | |
 Atypical lung carcinoid tumour. H&E stain. | |
|
| |
| Synonyms | atypical carcinoid, atypical pulmonary lung carcinoid |
| LM DDx | small cell carcinoma of the lung, carcinoid lung tumour, pulmonary carcinoid tumourlet, lung adenocarcinoma, metastatic small cell carcinoma |
| IHC | Ki-67 ~17% (range 10-26%) |
| Site | lung - see lung tumours |
|
| |
| Clin. DDx | other lung tumours |
Atypical carcinoid lung tumour, also atypical carcinoid, is an uncommon lung tumour with a poor outcome.
General
- Approximately 20% of lung carcinoids.[1]
Treatment:
- Surgery for diagnosis and treatment.
- Chemotherapy for advanced/metastatic disease.[2]
Microscopic
Features:[3]
- Nests of cells.
- Stippled chromatin.
- Mild-to-moderate amount of cytoplasm.
- No necrosis/focal necrosis.
- Moderate mitotic rate (2-10/HPF - definition suffers from HPFitis).
DDx:
- Typical carcinoid lung tumour.
- Small cell carcinoma of the lung.
- Metastatic small cell carcinoma.
- Lung adenocarcinoma.
Images
ALC - low mag.
ALC - intermed. mag.
ALC - high mag.
ALC - very high mag.
ALC - high mag.
ALC - very high mag.
ALC - extremely high mag.
IHC
- Ki-67 ~17% (range 10-26%).[4]
Note:
- Typical carcinoid is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).[4]
See also
References
- ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
- ↑ Chong, CR.; Wirth, LJ.; Nishino, M.; Chen, AB.; Sholl, LM.; Kulke, MH.; McNamee, CJ.; Jänne, PA. et al. (Nov 2014). "Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors.". Lung Cancer 86 (2): 241-6. doi:10.1016/j.lungcan.2014.08.012. PMID 25218177.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 115. ISBN 978-0781765275.
- ↑ 4.0 4.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.