Difference between revisions of "Renal oncocytosis"
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| Line 24: | Line 24: | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = multiple renal tumours | | Rads = multiple renal tumours (unilateral or bilateral) | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
Revision as of 04:19, 4 December 2015
| Renal oncocytosis | |
|---|---|
| Diagnosis in short | |
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| |
| LM | any mixture of oncocytic tumours - see hybrid tumour, chromophobe renal cell carcinoma and renal oncocytoma |
| LM DDx | other renal tumours with eosinophilic cytoplasm |
| IHC | characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour |
| Gross | multiple brown kidney nodules (bilateral or unilateral) |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | Birt–Hogg–Dubé syndrome |
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| |
| Clinical history | +/-chronic renal failure and hemodialysis |
| Prevalence | rare |
| Radiology | multiple renal tumours (unilateral or bilateral) |
| Clin. DDx | metastatic disease, multifocal renal cell carcinoma |
Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]
General
- Rare.
- May be seen in the context of Birt–Hogg–Dubé syndrome or chronic renal failure or may be sporadic.[1]
- Chronic renal failure seen in 50% of cases in one series.[2]
Gross
- Multiple (unilateral or bilateral) brown-coloured nodules.[1]
Microscopic
Features:
- Any mixture of oncocytic tumours (hybrid tumour, chromophobe renal cell carcinoma, renal oncocytoma).
DDx:
- Hybrid tumour.
- Chromophobe renal cell carcinoma.
- Renal oncocytoma.
- Other renal tumours with eosinophilic cytoplasm.
IHC
- Characteristic of the histologic appearance.[1]
- Stain like renal oncocytomas, chromophobe renal cell carcinomas and hybrid tumours.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
- ↑ Adamy, A.; Lowrance, WT.; Yee, DS.; Chong, KT.; Bernstein, M.; Tickoo, SK.; Coleman, JA.; Russo, P. (Mar 2011). "Renal oncocytosis: management and clinical outcomes.". J Urol 185 (3): 795-801. doi:10.1016/j.juro.2010.10.068. PMID 21239013.