Difference between revisions of "Male infertility"

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*[[Intratubular germ cell neoplasia]].
*[[Intratubular germ cell neoplasia]].
*[[Germ cell tumour]].
*[[Germ cell tumour]].
*[[Testicular adrenal rest tumour]] in the context of congenital adrenal hyperplasia - case report.<ref name=pmid23342900>{{Cite journal  | last1 = Niedziela | first1 = M. | last2 = Joanna | first2 = T. | last3 = Piotr | first3 = J. | title = Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report. | journal = Ginekol Pol | volume = 83 | issue = 9 | pages = 700-2 | month = Sep | year = 2012 | doi =  | PMID = 23342900 }}</ref>
*Inflammation of the testis.
*Inflammation of the testis.



Revision as of 04:04, 15 July 2015

Male infertility
Diagnosis in short

Mixed pattern male infertility (Sertoli cells only mixed with hypospermatogensis). H&E stain.

LM various patterns - see microscopic
LM DDx intratubular germ cell neoplasia, germ cell tumour, inflammation of the testis
Site testis, vas deferens and other sites

Prevalence not very common
Prognosis benign
Clin. DDx (clinical diagnosis)
Treatment dependent on underlying cause

Male infertility is a clinical diagnosis. It is pretty much the only reason for a testicular biopsy.

This article focuses on the testicular causes of infertility. Testicular biopsy redirects to here.

General

It can be divided into:[1]

Microscopic

Male infertility on testicular biopsy shows one the following patterns:[1]

  1. Normal testis.
  2. Hypospermatogensis.
  3. Maturation arrest.
  4. Sertoli cells only.
  5. Seminiferous tubule hyalinization
  6. A combination of the above.

DDx:

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  • The diagnosis should be the pattern (#1-6 above).

The following should be commented on:

Mixed pattern

LEFT TESTIS, BIOPSY FOR SPERM RETRIEVAL:
- SERTOLI CELLS ONLY REGIONS (25% OF BIOPSY) INTERMEIXED WITH
  HISTOLOGICALLY NORMAL TESTIS (75% OF BIOPSY) WITH NORMAL NUMBERS
  OF SPERM.
- NEGATIVE FOR SIGNIFICANT SEMINIFEROUS TUBULE HYALINIZATION.
- NEGATIVE FOR SIGNIFICANT INFLAMMATION.
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.

See also

References

  1. 1.0 1.1 Cerilli, LA.; Kuang, W.; Rogers, D. (Aug 2010). "A practical approach to testicular biopsy interpretation for male infertility.". Arch Pathol Lab Med 134 (8): 1197-204. doi:10.1043/2009-0379-RA.1. PMID 20670143.
  2. Niedziela, M.; Joanna, T.; Piotr, J. (Sep 2012). "Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report.". Ginekol Pol 83 (9): 700-2. PMID 23342900.