Difference between revisions of "Penile intraepithelial neoplasia"
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'''Penile intraepithelial neoplasia''', abbreviated '''PeIN''', is the precursor of [[squamous cell carcinoma of the penis]]. | '''Penile intraepithelial neoplasia''', abbreviated '''PeIN''', is the precursor of [[squamous cell carcinoma of the penis]]. | ||
It may be abbreviated '''PIN''';<ref name=pmid12452865>{{Cite journal | last1 = Porter | first1 = WM. | last2 = Francis | first2 = N. | last3 = Hawkins | first3 = D. | last4 = Dinneen | first4 = M. | last5 = Bunker | first5 = CB. | title = Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. | journal = Br J Dermatol | volume = 147 | issue = 6 | pages = 1159-65 | month = Dec | year = 2002 | doi = | PMID = 12452865 }}</ref> however, this can cause confusion with the [[prostatic intraepithelial neoplasia]] (the presursor of [[prostate carcinoma]]). | It may be abbreviated '''PIN''';<ref name=pmid12452865>{{Cite journal | last1 = Porter | first1 = WM. | last2 = Francis | first2 = N. | last3 = Hawkins | first3 = D. | last4 = Dinneen | first4 = M. | last5 = Bunker | first5 = CB. | title = Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. | journal = Br J Dermatol | volume = 147 | issue = 6 | pages = 1159-65 | month = Dec | year = 2002 | doi = | PMID = 12452865 }}</ref> however, this can cause confusion with the [[prostatic intraepithelial neoplasia]] (the presursor of [[prostate carcinoma]]). | ||
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DDx: | DDx: | ||
*[[Squamous cell carcinoma of the penis]]. | *[[Squamous cell carcinoma of the penis]]. | ||
===Subclassification=== | |||
Subclassified based on the role of [[HPV]],<ref>{{Cite journal | last1 = Velazquez | first1 = EF. | last2 = Chaux | first2 = A. | last3 = Cubilla | first3 = AL. | title = Histologic classification of penile intraepithelial neoplasia. | journal = Semin Diagn Pathol | volume = 29 | issue = 2 | pages = 96-102 | month = May | year = 2012 | doi = | PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]: | |||
*Conventional PeIN. | |||
*Differentiated PeIN. | |||
==IHC== | |||
*p16 -ve in dPeIN,<ref><ref>{{Cite journal | last1 = Oertell | first1 = J. | last2 = Caballero | first2 = C. | last3 = Iglesias | first3 = M. | last4 = Chaux | first4 = A. | last5 = Amat | first5 = L. | last6 = Ayala | first6 = E. | last7 = Rodríguez | first7 = I. | last8 = Velázquez | first8 = EF. | last9 = Barreto | first9 = JE. | title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. | journal = Histopathology | volume = 58 | issue = 6 | pages = 925-33 | month = May | year = 2011 | doi = 10.1111/j.1365-2559.2011.03816.x | PMID = 21585428 }}</ref></ref> +ve in cPeIN. | |||
==See also== | ==See also== | ||
Revision as of 04:04, 22 July 2015
Penile intraepithelial neoplasia, abbreviated PeIN, is the precursor of squamous cell carcinoma of the penis.
It may be abbreviated PIN;[1] however, this can cause confusion with the prostatic intraepithelial neoplasia (the presursor of prostate carcinoma).
General
- Not very common overall.
- Typically seen adjacent to squamous cell carcinoma of the penis.
Microscopic
See vulvar intraepithelial neoplasia.
DDx:
Subclassification
Subclassified based on the role of HPV,[2] as in vulvar intraepithelial neoplasia:
- Conventional PeIN.
- Differentiated PeIN.
IHC
- p16 -ve in dPeIN,Cite error: Closing
</ref>missing for<ref>tag</ref> +ve in cPeIN.
See also
References
- ↑ Porter, WM.; Francis, N.; Hawkins, D.; Dinneen, M.; Bunker, CB. (Dec 2002). "Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases.". Br J Dermatol 147 (6): 1159-65. PMID 12452865.
- ↑ Velazquez, EF.; Chaux, A.; Cubilla, AL. (May 2012). "Histologic classification of penile intraepithelial neoplasia.". Semin Diagn Pathol 29 (2): 96-102. PMID 22641959.