Difference between revisions of "Pseudoangiomatous stromal hyperplasia"
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(Fixed CD34 staining pattern (is positive).) Tags: Mobile edit Mobile web edit |
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| Subtypes = | | Subtypes = | ||
| LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]] | | LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]] | ||
| Stains = Bcl-2 +ve, vimentin +ve, CD34 | | Stains = Bcl-2 +ve, vimentin +ve, CD34 +ve, SMMHC +ve, CD31 -ve, factor VIII -ve | ||
| IHC = | | IHC = | ||
| EM = | | EM = |
Revision as of 00:09, 18 April 2018
Pseudoangiomatous stromal hyperplasia | |
---|---|
Diagnosis in short | |
Pseudoangiomatous stromal hyperplasia. H&E stain. | |
| |
LM | abundant breast stroma, small complex inter-anastomosing (blood vessel/capillary-like) channels |
LM DDx | fibroadenoma, low-grade angiosarcoma |
Stains | Bcl-2 +ve, vimentin +ve, CD34 +ve, SMMHC +ve, CD31 -ve, factor VIII -ve |
Site | breast |
| |
Signs | +/-breast mass |
Prevalence | uncommon |
Prognosis | benign |
Clin. DDx | fibroadenoma |
Treatment | followup or excision |
Pseudoangiomatous stromal hyperplasia, abbreviated PASH, is benign lesion is breast pathology.
It is also known as nodular myofibroblastic stromal hyperplasia of the mammary gland.[1]
General
- Benign lesion.
- Thought to arise due to myofibroblast abnormality - though not well understood.[2]
- An incidental finding or occasionally a mass.[3]
- May be suspicious on imaging (BI-RADS 4 or 5).[4]
- May be followed (expectant management) or (surgically) excised.[5]
Gross
Features:[2]
- May form mass.
- Grey-white & firm.
- Well-circumscribed borders.
Microscopic
- Abundant breast stromal.
- Small, complex, inter-anastomosing (blood vessel/capillary-like) channels - key feature.
- Pseudoangiomatous = blood vessel-like.
Notes:
- May mimic angiosarcoma at low power; PASH may have the same architecture but lack nuclear atypia.
- Occasionally has mitotic activity - proliferative PASH.
DDx:
Images
www:
IHC
Findings:[2]
See also
References
- ↑ Leon, ME.; Leon, MA.; Ahuja, J.; Garcia, FU.. "Nodular myofibroblastic stromal hyperplasia of the mammary gland as an accurate name for pseudoangiomatous stromal hyperplasia of the mammary gland.". Breast J 8 (5): 290-3. PMID 12199757.
- ↑ 2.0 2.1 2.2 Powell CM, Cranor ML, Rosen PP (March 1995). "Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation". Am. J. Surg. Pathol. 19 (3): 270–7. PMID 7872425.
- ↑ Drinka, EK.; Bargaje, A.; Erşahin, ÇH.; Patel, P.; Salhadar, A.; Sinacore, J.; Rajan, P. (Feb 2012). "Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases.". Int J Surg Pathol 20 (1): 54-8. doi:10.1177/1066896911418643. PMID 21862488.
- ↑ Wieman, SM.; Landercasper, J.; Johnson, JM.; Ellis, RL.; Wester, SM.; Lambert, PJ.; Ross, LA. (Dec 2008). "Tumoral pseudoangiomatous stromal hyperplasia of the breast.". Am Surg 74 (12): 1211-4. PMID 19097540.
- ↑ Jaunoo, SS.; Thrush, S.; Dunn, P. (2011). "Pseudoangiomatous stromal hyperplasia (PASH): a brief review.". Int J Surg 9 (1): 20-2. doi:10.1016/j.ijsu.2010.09.005. PMID 20887819.
- ↑ Vuitch MF, Rosen PP, Erlandson RA (February 1986). "Pseudoangiomatous hyperplasia of mammary stroma". Hum. Pathol. 17 (2): 185–91. PMID 3949338.
- ↑ 7.0 7.1 Ferreira, M.; Albarracin, CT.; Resetkova, E. (Feb 2008). "Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases.". Mod Pathol 21 (2): 201-7. doi:10.1038/modpathol.3801003. PMID 18084246.
- ↑ 8.0 8.1 Baker, M.; Chen, H.; Latchaw, L.; Memoli, V.; Ornvold, K. (Aug 2011). "Pseudoangiomatous stromal hyperplasia of the breast in a 10-year-old girl.". J Pediatr Surg 46 (8): e27-31. doi:10.1016/j.jpedsurg.2011.04.063. PMID 21843705.
- ↑ URL: http://surgpathcriteria.stanford.edu/breast/pash/printable.html. Accessed on: 28 April 2012.