Difference between revisions of "Apocrine carcinoma of the breast"

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*Often HER2 +ve but can be HER2 -ve.<ref name=pmid19898421>{{Cite journal  | last1 = Niemeier | first1 = LA. | last2 = Dabbs | first2 = DJ. | last3 = Beriwal | first3 = S. | last4 = Striebel | first4 = JM. | last5 = Bhargava | first5 = R. | title = Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. | journal = Mod Pathol | volume = 23 | issue = 2 | pages = 205-12 | month = Feb | year = 2010 | doi = 10.1038/modpathol.2009.159 | PMID = 19898421 }}</ref>
*Often HER2 +ve but can be HER2 -ve.<ref name=pmid19898421>{{Cite journal  | last1 = Niemeier | first1 = LA. | last2 = Dabbs | first2 = DJ. | last3 = Beriwal | first3 = S. | last4 = Striebel | first4 = JM. | last5 = Bhargava | first5 = R. | title = Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. | journal = Mod Pathol | volume = 23 | issue = 2 | pages = 205-12 | month = Feb | year = 2010 | doi = 10.1038/modpathol.2009.159 | PMID = 19898421 }}</ref>


Notes
Notes:
*Salivary gland carcinoma and cutaneous adnexal tumors can show a similar IHC profile.
*[[Salivary duct carcinoma]] and cutaneous adnexal tumours can show a similar IHC profile.
*Apocrine carcioma can be a non-basal type 'triple negative carcinoma' <ref>{{Cite journal  | last1 = Tsutsumi | first1 = Y. | title = Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma. | journal = Jpn J Clin Oncol | volume = 42 | issue = 5 | pages = 375-86 | month = May | year = 2012 | doi = 10.1093/jjco/hys034 | PMID = 22450930 }}</ref>.
*Apocrine carcioma can be a non-basal type 'triple negative carcinoma'.<ref name=pmid22450930>{{Cite journal  | last1 = Tsutsumi | first1 = Y. | title = Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma. | journal = Jpn J Clin Oncol | volume = 42 | issue = 5 | pages = 375-86 | month = May | year = 2012 | doi = 10.1093/jjco/hys034 | PMID = 22450930 }}</ref>
**May show different behaviour to other types of triple negative carcinoma
**May show different behaviour to other types of triple negative carcinoma.
**May respond to treatments targeting the androgen receptor<ref>{{Cite journal  | last1 = Safarpour | first1 = D. | last2 = Tavassoli | first2 = FA. | title = A Targetable Androgen Receptor-Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers. | journal = Arch Pathol Lab Med | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.5858/arpa.2014-0122-RA | PMID = 25310144 }}
**May respond to treatments targeting the androgen receptor.<ref name=pmid25310144>{{Cite journal  | last1 = Safarpour | first1 = D. | last2 = Tavassoli | first2 = FA. | title = A Targetable Androgen Receptor-Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers. | journal = Arch Pathol Lab Med | volume =  | issue =  | pages =  | month = Oct | year = 2014 | doi = 10.5858/arpa.2014-0122-RA | PMID = 25310144 }}</ref>
</ref>
*Be careful when reading the literature in this area - is the author discussing 'molecular apocrine' (ER -ve, AR +ve) or 'morphologic apocrine' carcinoma.   
*Be careful when reading the literature in this area - is the author discussing 'molecular apocrine' (ER -ve, AR +ve) or 'morphologic apocrine' carcinoma.   
*Many ductal carcinomas, NOS will show AR positivity but are often ER +ve.
*Many [[invasive ductal carcinoma of the breast|ductal carcinomas, NOS]] show AR positivity but are often ER +ve.


==See also==
==See also==

Revision as of 02:45, 2 April 2015

Apocrine carcinoma of the breast
Diagnosis in short

Apocrine carcinoma of the breast. H&E stain.
LM apocrine morphology (cells with prominent nucleoli - may be multiple, abundant granular eosinophilic cytoplasm) - must be >=90% of tumour, loss of basal cells
LM DDx glycogen-rich clear cell carcinoma of the breast
IHC AR +ve, GCDFP-15 +ve, ER -ve, PR -ve, HER2 +ve/-ve
Site breast - see invasive breast cancer
Prevalence uncommon
Prognosis poor, worse the ductal carcinoma
Clin. DDx other breast masses
Treatment excision

Apocrine carcinoma of the breast is a rare form of invasive breast cancer.

General

Microscopic

Features:[1]

  • Prominent nucleoli.
    • Often multiple.[3]
  • Abundant granular eosinophilic cytoplasm.
  • Architecture like invasive ductal carcinomas no special type.

DDx:

  • Glycogen-rich clear cell carcinoma of the breast.
  • Cutaneous Apocrine Carcinoma
      • A possible cutaneous apocrine carcinoma in a patient with a history of mammary apocrine carcinoma is problematic but fortunately a relatively infrequent conundrum.
  • Apocrine-like carcinoma - immunoprolife doesn't fit for invasive AC (ER +ve, PR +ve, AR -ve).[2]

Images

www:

  • Breast - Apocrine Carcinoma - Low power (SKB)

  • Breast - Apocrine Carcinoma - Perineural invasion - High power (SKB)

  • Breast - Apocrine Carcinoma - Low power (SKB)

  • Breast - Apocrine Carcinoma - Medium power (SKB)

  • Breast - Apocrine Carcinoma - High power (SKB)

  • Breast - Apocrine Carcinoma - High power (SKB)

IHC

Smaller tumours classically:[4]

Usually:[1]

  • ER -ve.
  • PR -ve.
  • Often HER2 +ve but can be HER2 -ve.[5]

Notes:

  • Salivary duct carcinoma and cutaneous adnexal tumours can show a similar IHC profile.
  • Apocrine carcioma can be a non-basal type 'triple negative carcinoma'.[6]
    • May show different behaviour to other types of triple negative carcinoma.
    • May respond to treatments targeting the androgen receptor.[7]
  • Be careful when reading the literature in this area - is the author discussing 'molecular apocrine' (ER -ve, AR +ve) or 'morphologic apocrine' carcinoma.
  • Many ductal carcinomas, NOS show AR positivity but are often ER +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066801.
  2. ↑ 2.0 2.1 Dellapasqua, S.; Maisonneuve, P.; Viale, G.; Pruneri, G.; Mazzarol, G.; Ghisini, R.; Mazza, M.; Iorfida, M. et al. (Apr 2013). "Immunohistochemically defined subtypes and outcome of apocrine breast cancer.". Clin Breast Cancer 13 (2): 95-102. doi:10.1016/j.clbc.2012.11.004. PMID 23245877.
  3. ↑ O'Malley, FP.; Bane, A. (Jan 2008). "An update on apocrine lesions of the breast.". Histopathology 52 (1): 3-10. doi:10.1111/j.1365-2559.2007.02888.x. PMID 18171412.
  4. ↑ Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.
  5. ↑ Niemeier, LA.; Dabbs, DJ.; Beriwal, S.; Striebel, JM.; Bhargava, R. (Feb 2010). "Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation.". Mod Pathol 23 (2): 205-12. doi:10.1038/modpathol.2009.159. PMID 19898421.
  6. ↑ Tsutsumi, Y. (May 2012). "Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma.". Jpn J Clin Oncol 42 (5): 375-86. doi:10.1093/jjco/hys034. PMID 22450930.
  7. ↑ Safarpour, D.; Tavassoli, FA. (Oct 2014). "A Targetable Androgen Receptor-Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers.". Arch Pathol Lab Med. doi:10.5858/arpa.2014-0122-RA. PMID 25310144.
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