Difference between revisions of "Astrocytoma"
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An '''astrocytoma''' is a neoplasm derived from an [[neurohistology|astrocyte]]. Astrocytomas are common. This article deals with, among other things, rare astrocytomas. An overview of CNS tumours is found in the ''[[CNS tumours]]'' article. | An '''astrocytoma''' is a neoplasm derived from an [[neurohistology|astrocyte]]. Astrocytomas are common. This article deals with, among other things, rare astrocytomas. An overview of CNS tumours is found in the ''[[CNS tumours]]'' article. | ||
=Other= | |||
==Pleomorphic xanthroastrocytoma== | |||
*Abbreviated ''PXA''. | |||
===General=== | |||
*Kids & young adults. | |||
*Prognosis usu. good. | |||
===Microscopic=== | |||
Features: | |||
*Large cells with intracytoplasmic lipid accumulation, i.e. foamy cytoplasm - '''key features'''.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm]. Accessed on: 13 January 2011.</ref> | |||
**May not be obvious/one may have to search for this. | |||
*Focal marked nuclear atypia - including hyperchromasia, marked nuclear enlargement, irregular chromatin. | |||
*Multinucleation - common. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Pleo_xantho.jpg PXA (WC/AFIP)]. | |||
*[http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm PXA (ouhsc.edu)]. | |||
*[http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970469-7&figureId=fig1&ddx=true PXA (pathconsultddx.com)]. | |||
===IHC=== | |||
Features:<Ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970469-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970469-7]. Accessed on: 13 January 2011.</ref> | |||
*GFAP +ve -- required for Dx, may be patchy. | |||
*S-100 +ve -- cytoplasm, usu. diffuse. | |||
=Glioblastoma= | =Glioblastoma= | ||
Revision as of 17:31, 13 January 2011
An astrocytoma is a neoplasm derived from an astrocyte. Astrocytomas are common. This article deals with, among other things, rare astrocytomas. An overview of CNS tumours is found in the CNS tumours article.
Other
Pleomorphic xanthroastrocytoma
- Abbreviated PXA.
General
- Kids & young adults.
- Prognosis usu. good.
Microscopic
Features:
- Large cells with intracytoplasmic lipid accumulation, i.e. foamy cytoplasm - key features.[1]
- May not be obvious/one may have to search for this.
- Focal marked nuclear atypia - including hyperchromasia, marked nuclear enlargement, irregular chromatin.
- Multinucleation - common.
Images:
IHC
Features:[2]
- GFAP +ve -- required for Dx, may be patchy.
- S-100 +ve -- cytoplasm, usu. diffuse.
Glioblastoma
Gliosarcoma
General
- Considered to be a variant of glioblastoma by WHO.[3]
- Rare ~ 200 cases reported in the literature.[3]
- Definition: gliosarcoma = glioblastoma + sarcomatous component.[4]
- Usual location (like glioblastoma): temporal lobe.
Microscopic
Features:
- Glioblastoma.
- Sarcomatous component (one of the following):[3][4]
- Fibroblastic.
- Cartilaginous.
- Osseous.
- Smooth muscle.
- Striated muscle.
- Adipocyte.
Image: Gliosarcoma - elastic von Gieson (WC).
See also
References
- ↑ URL: http://moon.ouhsc.edu/kfung/jty1/neurotest/Q14-Ans.htm. Accessed on: 13 January 2011.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970469-7. Accessed on: 13 January 2011.
- ↑ 3.0 3.1 3.2 Han SJ, Yang I, Tihan T, Prados MD, Parsa AT (February 2010). "Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity". J. Neurooncol. 96 (3): 313–20. doi:10.1007/s11060-009-9973-6. PMC 2808523. PMID 19618114. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808523/.
- ↑ 4.0 4.1 Ayadi L, Charfi S, Khabir A, et al. (March 2010). "[Cerebral gliosarcoma: clinico-pathologic study of 8 cases]" (in French). Tunis Med 88 (3): 142–6. PMID 20415184.