Difference between revisions of "Chondromyxoid fibroma"
Jump to navigation
Jump to search
| Line 43: | Line 43: | ||
==See also== | ==See also== | ||
*[[Chondro-osseous tumours]]. | *[[Chondro-osseous tumours]]. | ||
*UMDNJ Tutor Web [http://njms2.umdnj.edu/tutorweb/case4.htm] | |||
*Pathology Outline [http://www.pathologyoutlines.com/topic/bonechondromyxoidfibroma.html] | |||
==References== | ==References== | ||
Revision as of 12:00, 12 November 2014
Chondromyxoid fibroma is a rare benign chondro-osseous tumour typically found in the metaphysis of teenagers or young adults.
General
- Uncommon and benign.[1]
- Teenagers or young adults.
Gross
- Metaphyseal lesion - classic location.[2]
- Well-circumscribed.
- Fragments of white-grey rubbery tissue
Microscopic
Features:[3]
- Spindle cells or stellate cells in a myxoid or chondroid stroma.
- Lobules with hypocellular centers and hypercellular peripheries.
- Giant cells in the hypercellular periphery
- Scattered calcifications
- No true hyaline cartilage matrix
- Lack of mitotic activity
DDx:
- Phosphaturic mesenchymal tumour - case report.[4]
- Chondroblastoma
- Also produces immature cartilage but
- Epiphyseal location
- Chicken-wire calcifications
- Chondrosarcoma
- Mature hyaline cartilage formation
- Tumor permeation of the surrounding bone
- Mitotic activity
Images:
- Chondromyxoid fibroma - low mag. (webpathology.com).
- Chondromyxoid fibroma - high mag. (webpathology.com).
- Tumor Library [1]
- Tumor Library [2]
- Tumor Library [3]
- Tumor Library [4]
- Tumor Library [5]
- Tumor Library [6]
![[1]](http://www.tumorlibrary.com/case/images/1490.jpg){kind=link}
![[2]](http://www.tumorlibrary.com/case/images/1491.jpg){kind=link}
![[3]](http://www.tumorlibrary.com/case/images/3618.jpg){kind=link}
![[4]](http://www.tumorlibrary.com/case/images/3619.jpg){kind=link}
![[5]](http://www.tumorlibrary.com/case/images/3621.jpg){kind=link}
![[6]](http://www.tumorlibrary.com/case/images/3623.jpg){kind=link}
Molecular
- Activating rearrangements of GRM1 (metabotropic glutamate receptor 1)[5]
See also
- Chondro-osseous tumours.
- UMDNJ Tutor Web [7]
- Pathology Outline [8]
References
- ↑ Bhamra, JS.; Al-Khateeb, H.; Dhinsa, BS.; Gikas, PD.; Tirabosco, R.; Pollock, RC.; Skinner, JA.; Aston, WJ. et al. (2014). "Chondromyxoid fibroma management: a single institution experience of 22 cases.". World J Surg Oncol 12: 283. doi:10.1186/1477-7819-12-283. PMID 25217119.
- ↑ Budny, AM.; Ismail, A.; Osher, L.. "Chondromyxoid fibroma.". J Foot Ankle Surg 47 (2): 153-9. doi:10.1053/j.jfas.2007.08.013. PMID 18312923.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 642. ISBN 978-0781765275.
- ↑ Suryawanshi, P.; Agarwal, M.; Dhake, R.; Desai, S.; Rekhi, B.; Reddy, KB.; Jambhekar, NA. (Nov 2011). "Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance.". Skeletal Radiol 40 (11): 1481-5. doi:10.1007/s00256-011-1159-6. PMID 21533894.
- ↑ Nord, KH.; Lilljebjörn, H.; Vezzi, F.; Nilsson, J.; Magnusson, L.; Tayebwa, J.; de Jong, D.; Bovée, JV. et al. (May 2014). "GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.". Nat Genet 46 (5): 474-7. doi:10.1038/ng.2927. PMID 24658000.