Difference between revisions of "Thyroid-like follicular carcinoma of the kidney"
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==General== | ==General== | ||
*Extremely rare. | *Extremely rare - less than 15 cases reported in the literature.<ref name=pmid24025519/> | ||
*Large age range (29-83 years old). | |||
==Gross== | |||
*Solid, brown and well circumscribed. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid24025519/> | ||
*Thyroid follicule-like structures | *Thyroid follicule-like structures - both microfollicular and/or microfollicular. **Contain dense-appearing eosinophilic material. | ||
*Encapuslated. | |||
*Nuclei round and regular with prominent nucleoli ([[ISUP nucleolar grade]] 2 or 3). | |||
DDx: | |||
*Metastatic carcinoma. | |||
**[[Follicular thyroid carcinoma]]. | |||
**[[Papillary thyroid carcinoma follicular variant]]. | |||
==IHC== | |||
Features:<ref name=pmid24025519/> | |||
*TTF-1 -ve. | |||
*Thyroglobulin -ve. | |||
*CK7 +ve/-ve. | |||
*PAX8 +ve/-ve. | |||
==See also== | ==See also== | ||
Revision as of 21:10, 23 October 2014
Thyroid-like follicular carcinoma of the kidney is a recently described rare kidney tumour.
It is considered an emerging entity by the Vancouver modification of the 2004 WHO classification of renal neoplasia.[1]
General
- Extremely rare - less than 15 cases reported in the literature.[1]
- Large age range (29-83 years old).
Gross
- Solid, brown and well circumscribed.
Microscopic
Features:[1]
- Thyroid follicule-like structures - both microfollicular and/or microfollicular. **Contain dense-appearing eosinophilic material.
- Encapuslated.
- Nuclei round and regular with prominent nucleoli (ISUP nucleolar grade 2 or 3).
DDx:
- Metastatic carcinoma.
IHC
Features:[1]
- TTF-1 -ve.
- Thyroglobulin -ve.
- CK7 +ve/-ve.
- PAX8 +ve/-ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.