Difference between revisions of "Mantle cell lymphoma"
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| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = poor | | Prognosis = moderately aggressive to poor | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
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==General== | ==General== | ||
*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref> | *Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref> | ||
*Rare ~ 2% of non-Hogkin's lymphoma in a series of over 4000 patients.<ref name=pmid18723950>{{cite journal |author=Gujral S, Agarwal A, Gota V, ''et al.'' |title=A clinicopathologic study of mantle cell lymphoma in a single center study in India |journal=Indian J Pathol Microbiol |volume=51 |issue=3 |pages=315–22 |year=2008 |pmid=18723950 |doi= |url=}}</ref> | |||
GI tract - typically:<ref name=pmid22236942/> | GI tract - typically:<ref name=pmid22236942/> | ||
*Abdominal pain (~37% of cases) or GI bleeding (~26% of cases). | *Abdominal pain (~37% of cases) or GI bleeding (~26% of cases). | ||
Revision as of 11:56, 14 May 2014
| Mantle cell lymphoma | |
|---|---|
| Diagnosis in short | |
 Mantle cell lymphoma. H&E stain. | |
|
| |
| LM | small monomorphic (uniform size, shape and staining) lymphoid population with abundant mitoses, +/-scattered epithelioid histiocytes (should not be confused with tingible-body macrophages), +/-sclerosed blood vessels |
| Subtypes | blastic variant |
| LM DDx | other small cell lymphomas (esp. MALT lymphoma), Burkitt lymphoma |
| IHC | cyclin D1 +ve, CD5 +ve, CD43 +ve, CD20 +ve, CD23 -ve |
| Molecular | t(11;14)(q13;q32) / IGH-CCND1 |
| Site | lymph node, GI tract, other sites |
|
| |
| Prevalence | not common |
| Prognosis | moderately aggressive to poor |
Mantle cell lymphoma, abbreviated MCL, is less common small cell lymphoma that is relatively aggressive when compared to other small cell lymphomas.
General
- Relatively aggressive - guarded prognosis.[1]
- Rare ~ 2% of non-Hogkin's lymphoma in a series of over 4000 patients.[2]
GI tract - typically:[3]
- Abdominal pain (~37% of cases) or GI bleeding (~26% of cases).
Gross
- GI tract: polypoid lesions (~50% of cases).[3]
Microscopic
Features:[4]
- Small monomorphic (uniform size, shape and staining) lymphoid population.
- Abundant mitoses.
- Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
- Sclerosed blood vessels.
DDx:
- Other small cell lymphomas, esp. marginal zone lymphoma.
- Burkitt's lymphoma.
Images
MCL - low mag. (WC)
MCL - intermed. mag. (WC)
MCL - low mag. - cyclin D1. (WC)
MCL - intermed. mag. - cyclin D1. (WC)
www:
IHC
- CD45 +ve.
- CD20 +ve.
- CD79a +ve.
- CD5 +ve -- important.
- Negative in case reports.[5]
- CD43 +ve.
- Cyclin D1 +ve -- key immunostain.
Others:
- CD23 -ve.
- Positive in CLL.
Molecular
- t(11;14)(q13;q32) / IGH-CCND1.[7]
See also
References
- ↑ Hankin, RC.; Hunter, SV. (Dec 1999). "Mantle cell lymphoma.". Arch Pathol Lab Med 123 (12): 1182-8. doi:10.1043/0003-9985(1999)1231182:MCL2.0.CO;2. PMID 10583923.
- ↑ Gujral S, Agarwal A, Gota V, et al. (2008). "A clinicopathologic study of mantle cell lymphoma in a single center study in India". Indian J Pathol Microbiol 51 (3): 315–22. PMID 18723950.
- ↑ 3.0 3.1 Kim, JH.; Jung, HW.; Kang, KJ.; Min, BH.; Lee, JH.; Chang, DK.; Kim, YH.; Son, HJ. et al. (2012). "Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement.". Acta Haematol 127 (3): 129-34. doi:10.1159/000333139. PMID 22236942.
- ↑ Good, D. 17 August 2010.
- ↑ URL: http://path.upmc.edu/cases/case308/dx.html. Accessed on: 14 January 2012.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
- ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.