Difference between revisions of "Solitary fibrous tumour"

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Features - benign:
Features - benign:
*Spindle cells in a patternless pattern.
*Spindle cells in a patternless pattern.
**Occasionally epithelioid cells - rare.<ref name=pmid17577399>{{Cite journal  | last1 = Martorell | first1 = M. | last2 = Pérez-Vallés | first2 = A. | last3 = Gozalbo | first3 = F. | last4 = Garcia-Garcia | first4 = JA. | last5 = Gutierrez | first5 = J. | last6 = Gaona | first6 = J. | title = Solitary fibrous tumor of the thigh with epithelioid features: a case report. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 19 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-19 | PMID = 17577399 }}</ref>
*Hemangiopericytoma-like area ([[staghorn vessels]]).
*Hemangiopericytoma-like area ([[staghorn vessels]]).
*Keloid-like collagen bundles - '''key feature'''.
*Keloid-like collagen bundles - '''key feature'''.

Revision as of 15:44, 18 February 2014

Solitary fibrous tumour
Diagnosis in short

Solitary fibrous tumour. H&E stain.

LM spindle cells in a patternless pattern, hemangiopericytoma-like areas (staghorn vessels), keloid-like collagen bundles, +/-well-circumscribed (common)
Subtypes benign (common), malignant (uncommon)
IHC CD34 ~90% +ve, CD99 ~70% +ve, BCL2 ~50% +ve
Site soft tissue - fibroblastic/myofibroblastic tumours, pleura

Syndromes Doege-Potter syndrome

Prognosis usu. good

Solitary fibrous tumour, abbreviated SFT, is a type of soft tissue tumour that fits in the fibroblastic/myofibroblastic tumours. It is usually benign.

SFT of the pleura is dealt with in a separate article solitary fibrous tumour of the pleura.

General

  • Grouped with hemangiopericytoma in the WHO classification - as it is thought to be the same tumour.[1]
  • May be benign or malignant; more commonly benign.[2][3]
  • May be associated with hypoglycemia.
    • Known as Doege-Potter syndrome.[4]

Gross

  • Soft tissue mass.

Microscopic

Features - benign:

  • Spindle cells in a patternless pattern.
    • Occasionally epithelioid cells - rare.[5]
  • Hemangiopericytoma-like area (staghorn vessels).
  • Keloid-like collagen bundles - key feature.
  • +/-Well-circumscribed (common).

Criteria for malignancy:[1]

  • Necrosis.
  • Mitoses >4/10 HPF -- definition suffers from HPFitis.
  • Increased cellularity.
  • Marked nuclear atypia.
  • Infiltrative margin.

Images

www:

IHC

  • CD34 ~90% +ve.
  • CD99 ~70% +ve.
  • BCL2 ~50% +ve.

See also

References

  1. 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 609. ISBN 978-0781765275.
  2. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9. Accessed on: 25 June 2010.
  3. URL: http://wjso.com/content/6/1/86. Accessed on: 25 June 2010.
  4. Roy, TM.; Burns, MV.; Overly, DJ.; Curd, BT. (Nov 1992). "Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome.". J Ky Med Assoc 90 (11): 557-60. PMID 1474302.
  5. Martorell, M.; Pérez-Vallés, A.; Gozalbo, F.; Garcia-Garcia, JA.; Gutierrez, J.; Gaona, J. (2007). "Solitary fibrous tumor of the thigh with epithelioid features: a case report.". Diagn Pathol 2: 19. doi:10.1186/1746-1596-2-19. PMID 17577399.