Difference between revisions of "Small cell lymphomas"

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Small cell lymphomas (view source)

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→‎B cell small lymphocytic lymphoma/chronic lymphocytic leukemia: spli tout
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==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==
==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==
*Abbreviated ''CLL'' and ''SLL''.
{{Main|B cell small lymphocytic lymphoma/chronic lymphocytic leukemia}}
===General===
*Very common.
*Good prognosis.
 
====Richter's transformation====
*CLL/SLL may under go a ''Richter's transformation'' into a high-grade non-Hodgkin's lymphoma (NHL), e.g. [[DLBCL]]:<ref name=pmid16616072>{{cite journal |author=Tsimberidou AM, Keating MJ |title=Richter's transformation in chronic lymphocytic leukemia |journal=Semin. Oncol. |volume=33 |issue=2 |pages=250–6 |year=2006 |month=April |pmid=16616072 |doi=10.1053/j.seminoncol.2006.01.016 |url=}}</ref>
**Incidence of transformation <5%.
**Prognosis < 1 year.
 
===Microscopic===
Features in a lymph node:<ref>DG. 17 August 2010.</ref>
*Mixed population of lymphoid cells with "proliferation centers" - '''key feature''':
*#Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers):
*#*Nucleoli.
*#*Form (nodular) collections.
*#Small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers):
*#*Predominant population.
*#*Lack nucleolus.
 
====Images====
<gallery>
Image:Chronic lymphocytic leukemia - low mag.jpg | CLL - low mag. (WC)
Image:Chronic lymphocytic leukemia - intermed mag.jpg | CLL - intermed. mag. (WC)
Image:Chronic lymphocytic leukemia - high mag.jpg | CLL - high mag. (WC)
Image:Chronic lymphocytic leukemia - very high mag.jpg | CLL - very high mag. (WC)
</gallery>
www:
*[http://www.pathologyatlas.ro/chronic-lymphoid-leukemia-liver.php CLL in the liver (pathologyatlas.ro)].
*[http://path.upmc.edu/cases/case296.html SLL in the parotid - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case446.html CLL with Richter transformation - several images (upmc.edu)].
 
===IHC===
*CD20 +ve.
*CD5 +ve.
*[[CD23]] +ve -- occasionally negative.<ref>URL: [http://path.upmc.edu/cases/case296/dx.html http://path.upmc.edu/cases/case296/dx.html]. Accessed on: 14 January 2012.</ref>
*CD43 +ve.
 
Others:
*Cyclin D1 -ve.
 
===Molecular===
*Lacks t(11;14) seen in [[mantle cell lymphoma]].


==Precursor B-cell lymphoblastic lymphoma/leukemia ==
==Precursor B-cell lymphoblastic lymphoma/leukemia ==
Michael
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