Difference between revisions of "Uterine cervix with atrophic changes"
Jump to navigation
Jump to search
m (rework) Tag: Mobile edit |
Tag: Mobile edit |
||
| Line 40: | Line 40: | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features - squamous cells: | ||
*Cells smaller. | *Cells smaller. | ||
*Cytoplasm grey/blue. | *Cytoplasm grey/blue. | ||
*No "dancing"/"sparkling" chromatin. | *No "dancing"/"sparkling" chromatin. | ||
*No mitoses. | *No mitoses. | ||
Notes: | |||
*Mitosis do not exclude the diagnosis.... should make one consider HSIL. | |||
DDx: | DDx: | ||
Revision as of 19:17, 18 January 2014
| Uterine cervix with atrophic changes | |
|---|---|
| Diagnosis in short | |
 Atrophic cervix. H&E stain. | |
|
| |
| LM | small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses |
| LM DDx | HSIL, immature squamous metaplasia |
| IHC | p16 -ve, Ki-67 rare basal cells |
| Site | uterine cervix - exocervix |
|
| |
| Clinical history | usually postmenopausal |
| Prevalence | common |
| Prognosis | benign |
| Other | normal - postmenopausal |
Uterine cervix with atrophic changes is relatively common and is important to recognize as it can mimic HSIL.
It is also known as atrophy of the uterine cervix, cervical atrophy, atrophy of the cervix and cervix with atrophic changes.
General
- Common.
- Post-menupausal.
- Important to recognize and differentiate from HSIL.
Microscopic
Features - squamous cells:
- Cells smaller.
- Cytoplasm grey/blue.
- No "dancing"/"sparkling" chromatin.
- No mitoses.
Notes:
- Mitosis do not exclude the diagnosis.... should make one consider HSIL.
DDx:
- HSIL.
- Immature squamous metaplasia.[1]
Images
AC - intermed. mag. (WC)
AC - high mag. (WC)
AC - high mag. (WC)
AC - very high mag. (WC)
AC - intermed. mag. (WC)
AC - high mag. (WC)
AC - very high mag. (WC)
www:
- Atrophic cervix (nih.techriver.net).
- Atrophic cervix (flickriver.com/euthman).
- Atrophic changes in the vagina (eurocytology.eu).[2]
IHC
Features:[1]
- p16 -ve.
- Ki-67 rare basal cells.
Sign out
UTERINE CERVIX, BIOPSY: - SQUAMOUS MUCOSA WITH ATROPHIC CHANGES. - BENIGN ENDOCERVICAL EPITHELIUM. - NEGATIVE FOR DYSPLASIA. COMMENT: A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells.
See also
References
- ↑ 1.0 1.1 Iaconis, L.; Hyjek, E.; Ellenson, LH.; Pirog, EC. (Sep 2007). "p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection.". Arch Pathol Lab Med 131 (9): 1343-9. doi:10.1043/1543-2165(2007)131[1343:PAKIIA]2.0.CO;2. PMID 17824788.
- ↑ URL: http://www.eurocytology.eu/static/eurocytology/TUR/cervical/LP1ContentLcontC.html. Accessed on: 13 December 2013.