Difference between revisions of "Small cell carcinoma of the urinary bladder"

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==General==
==General==
*Very rare.<ref name=pmid24168010>{{Cite journal  | last1 = Koga | first1 = F. | last2 = Yokoyama | first2 = M. | last3 = Fukushima | first3 = H. | title = Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments. | journal = Expert Rev Anticancer Ther | volume = 13 | issue = 11 | pages = 1269-79 | month = Nov | year = 2013 | doi = 10.1586/14737140.2013.851605 | PMID = 24168010 }}</ref>
*Very rare<ref name=pmid24168010>{{Cite journal  | last1 = Koga | first1 = F. | last2 = Yokoyama | first2 = M. | last3 = Fukushima | first3 = H. | title = Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments. | journal = Expert Rev Anticancer Ther | volume = 13 | issue = 11 | pages = 1269-79 | month = Nov | year = 2013 | doi = 10.1586/14737140.2013.851605 | PMID = 24168010 }}</ref> - less than 1% of bladder cancers in one series.<ref name=pmid24009428>{{Cite journal  | last1 = Hou | first1 = CP. | last2 = Lin | first2 = YH. | last3 = Chen | first3 = CL. | last4 = Chang | first4 = PL. | last5 = Tsui | first5 = KH. | title = Clinical outcome of primary small cell carcinoma of the urinary bladder. | journal = Onco Targets Ther | volume = 6 | issue =  | pages = 1179-85 | month =  | year = 2013 | doi = 10.2147/OTT.S49879 | PMID = 24009428 }}</ref>
*Poor prognosis.<ref name=pmid24168010/>
*Poor prognosis<ref name=pmid24168010/> - survival ~ 11 months.<ref name=pmid24009428/>
 
Clinical:
*Hematuria - typical presentation.<ref name=pmid24009428/>
 
Epidemiology:
*[[Smoking]] - very common.<ref name=pmid24009428/>


==Microscopic==
==Microscopic==
Features:
Features:
*See ''[[small cell carcinoma]]''.
*See ''[[small cell carcinoma]]''.
Note:
*Usually co-exists with [[urothelial carcinoma]] ~60% of cases in one series.<ref name=pmid24009428/>


DDx:
DDx:

Revision as of 03:25, 6 January 2014

Small cell carcinoma of the urinary bladder
Diagnosis in short

Small cell carcinoma of the urinary bladder. H&E stain.
LM DDx small cell carcinoma of the prostate gland, lymphoma (large cell), other small round blue cell tumours
Stains pankeratin +ve, chromogranin +ve, synaptophysin +ve, CD56 +ve
Site urinary bladder
Symptoms +/-hematuria
Prevalence very rare
Prognosis poor
Clin. DDx other bladder tumours esp. urothelial carcinoma

Small cell carcinoma of the urinary bladder, abbreviated SCCUB, is a rare malignant neoplasm of the urinary bladder.

General

  • Very rare[1] - less than 1% of bladder cancers in one series.[2]
  • Poor prognosis[1] - survival ~ 11 months.[2]

Clinical:

  • Hematuria - typical presentation.[2]

Epidemiology:

Microscopic

Features:

Note:

DDx:

Images

  • SmCC bladder - intermed. mag.

  • SmCC bladder - high mag.

  • SmCC bladder - very high mag.

IHC

  • Pankeratin +ve,
  • Chromogranin +ve.
  • Synaptophysin +ve.
  • CD56 +ve.

See also

References

  1. ↑ 1.0 1.1 Koga, F.; Yokoyama, M.; Fukushima, H. (Nov 2013). "Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments.". Expert Rev Anticancer Ther 13 (11): 1269-79. doi:10.1586/14737140.2013.851605. PMID 24168010.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Hou, CP.; Lin, YH.; Chen, CL.; Chang, PL.; Tsui, KH. (2013). "Clinical outcome of primary small cell carcinoma of the urinary bladder.". Onco Targets Ther 6: 1179-85. doi:10.2147/OTT.S49879. PMID 24009428.
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