Difference between revisions of "Lymphocytic mastitis"
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'''Lymphocytic mastitis''' is a rare pathology of the [[breast]]. | |||
==General== | |||
*If the individual has [[diabetes mellitus]] (DM) it is called ''diabetic mastopathy''.<ref name=pmid12640102>{{Cite journal | last1 = Valdez | first1 = R. | last2 = Thorson | first2 = J. | last3 = Finn | first3 = WG. | last4 = Schnitzer | first4 = B. | last5 = Kleer | first5 = CG. | title = Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 223-8 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056627.21128.74 | PMID = 12640102 }}</ref> | |||
*Rare. | |||
==Microscopic== | |||
Features:<ref>URL: [http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html]. Accessed on: 28 November 2010.</ref> | |||
* Lymphocytic infiltrates - '''key feature''': | |||
** Lobules. | |||
** Perivascular. | |||
* Enlarged stromal fibroblasts. | |||
* Stromal collagen with keloid-like changes. | |||
DDx: | |||
*Diabetic mastopathy - if individual has diabetes. | |||
*Primary [[lymphoma]] of the breast. | |||
===Images=== | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=655 Lymphocytic mastitis - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=655&n=2 Lymphocytic mastitis - high mag. (webpathology.com)]. | |||
==IHC== | |||
*B cell predominant (CD20 > CD3).<ref name=pmid12640102/> | |||
**B cells CD43 -ve. | |||
==Molecular== | |||
*Negative clonality studies. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||
Revision as of 04:41, 16 February 2014
Lymphocytic mastitis is a rare pathology of the breast.
General
- If the individual has diabetes mellitus (DM) it is called diabetic mastopathy.[1]
- Rare.
Microscopic
Features:[2]
- Lymphocytic infiltrates - key feature:
- Lobules.
- Perivascular.
- Enlarged stromal fibroblasts.
- Stromal collagen with keloid-like changes.
DDx:
- Diabetic mastopathy - if individual has diabetes.
- Primary lymphoma of the breast.
Images
www:
- Lymphocytic mastitis - low mag. (webpathology.com).
- Lymphocytic mastitis - high mag. (webpathology.com).
IHC
- B cell predominant (CD20 > CD3).[1]
- B cells CD43 -ve.
Molecular
- Negative clonality studies.
See also
References
- ↑ 1.0 1.1 Valdez, R.; Thorson, J.; Finn, WG.; Schnitzer, B.; Kleer, CG. (Mar 2003). "Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases.". Mod Pathol 16 (3): 223-8. doi:10.1097/01.MP.0000056627.21128.74. PMID 12640102.
- ↑ URL: http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html. Accessed on: 28 November 2010.