Difference between revisions of "Squamous metaplasia of the uterine cervix"

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#redirect [[Uterine_cervix#Squamous_metaplasia_of_the_uterine_cervix]]
'''Squamous metaplasia of the uterine cervix''' is a common change of the [[uterine cervix]] that may resemble [[squamous intraepithelial lesion]].


<!-- [[Category:Diagnosis]] -->
It may be abbreviated '''SMC'''.
 
==General==
*Benign process: columnar cells -> squamoid cells.
**Biologic response to irritation and/or inflammation.
 
==Gross==
*[[Acetowhite epithelium|Acetowhite lesion]].<ref name=pmid19256708>{{Cite journal  | last1 = Li | first1 = W. | last2 = Venkataraman | first2 = S. | last3 = Gustafsson | first3 = U. | last4 = Oyama | first4 = JC. | last5 = Ferris | first5 = DG. | last6 = Lieberman | first6 = RW. | title = Using acetowhite opacity index for detecting cervical intraepithelial neoplasia. | journal = J Biomed Opt | volume = 14 | issue = 1 | pages = 014020 | month =  | year =  | doi = 10.1117/1.3079810 | PMID = 19256708 }}</ref>
 
==Microscopic==
Features:
* Uniform cell spacing - no crowding - '''key feature'''.
* Nuclei are uniform size and round.
** [[Nucleoli]] present.
*Distinct cell borders
* +/-Intercellular bridges (due to edema) - common.
* Adjacent/closely associated with columnar epithelium.
** Columnar epithelium superficial in immature metaplasia.
 
Negatives:
* No mitoses (think cancer/CIN if you see 'em).
* Usually no hyperchromatism (think cancer/CIN if you see it).
 
Notes:
*NC ratio high - possible to confuse with CIN III.
*May have goblet cells - uncommon.<ref name=pmid21077478>{{Cite journal  | last1 = Sivridis | first1 = E. | last2 = Karpathiou | first2 = G. | last3 = Malamou-Mitsi | first3 = V. | last4 = Giatromanolaki | first4 = A. | title = Intestinal-type metaplasia in the original squamous epithelium of the cervix. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 3 | pages = 319-22 | month =  | year = 2010 | doi =  | PMID = 21077478 }}</ref>
 
DDx:
*[[CIN II]] - esp. for immature squamous metaplasia.
*[[CIN III]].
*[[Squamous cell carcinoma of the uterine cervix]].
 
===Images===
*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].
*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].
*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].
*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>
 
==IHC==
*p16 weak-to-moderate patchy +ve -- checkerboard-like; not full thickness.
**Strong diffuse full thickness positivity in HSIL and SCC.
*Ki-67 - low proliferative rate.
 
==Sign out==
===ECC===
<pre>
UTERINE ENDOCERVIX, CURETTAGE:
- SQUAMOUS METAPLASTIC EPITHELIUM.
- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.
</pre>
 
===Cervical biopsy===
<pre>
UTERINE CERVIX, BIOPSY:
- SQUAMOUS METAPLASTIC EPITHELIUM.
- SCANT BENIGN ENDOCERVICAL GLANDS.
</pre>
 
<pre>
UTERINE CERVIX, BIOPSY:
- SQUAMOUS METAPLASTIC EPITHELIUM.
- SCANT BENIGN ENDOCERVICAL GLANDS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
</pre>
 
===Micro===
The sections show stratified squamous epithelium. The cells are equally spaced and spaces are seen between the cells (edema). 
 
The nuclei are not significantly enlarged (<3x resting lymphocyte diameter). No nuclear halos are apparent.  The nuclear membranes are regular.  Mild inflammation is present. Nucleoli are present focally.
 
No endocervical cells are identified.
 
==See also==
*[[Squamous metaplasia]].
*[[Uterine cervix]].
 
==References==
{{Reflist|2}}
 
[[Category:Uterine cervix]]
[[Category:Diagnosis]]

Revision as of 01:54, 6 May 2014

Squamous metaplasia of the uterine cervix is a common change of the uterine cervix that may resemble squamous intraepithelial lesion.

It may be abbreviated SMC.

General

  • Benign process: columnar cells -> squamoid cells.
    • Biologic response to irritation and/or inflammation.

Gross

Microscopic

Features:

  • Uniform cell spacing - no crowding - key feature.
  • Nuclei are uniform size and round.
  • Distinct cell borders
  • +/-Intercellular bridges (due to edema) - common.
  • Adjacent/closely associated with columnar epithelium.
    • Columnar epithelium superficial in immature metaplasia.

Negatives:

  • No mitoses (think cancer/CIN if you see 'em).
  • Usually no hyperchromatism (think cancer/CIN if you see it).

Notes:

  • NC ratio high - possible to confuse with CIN III.
  • May have goblet cells - uncommon.[2]

DDx:

Images

IHC

  • p16 weak-to-moderate patchy +ve -- checkerboard-like; not full thickness.
    • Strong diffuse full thickness positivity in HSIL and SCC.
  • Ki-67 - low proliferative rate.

Sign out

ECC

UTERINE ENDOCERVIX, CURETTAGE: 
- SQUAMOUS METAPLASTIC EPITHELIUM.
- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.

Cervical biopsy

UTERINE CERVIX, BIOPSY: 
- SQUAMOUS METAPLASTIC EPITHELIUM.
- SCANT BENIGN ENDOCERVICAL GLANDS.

UTERINE CERVIX, BIOPSY: 
- SQUAMOUS METAPLASTIC EPITHELIUM.
- SCANT BENIGN ENDOCERVICAL GLANDS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.

Micro

The sections show stratified squamous epithelium. The cells are equally spaced and spaces are seen between the cells (edema).

The nuclei are not significantly enlarged (<3x resting lymphocyte diameter). No nuclear halos are apparent. The nuclear membranes are regular. Mild inflammation is present. Nucleoli are present focally.

No endocervical cells are identified.

See also

References

  1. ↑ Li, W.; Venkataraman, S.; Gustafsson, U.; Oyama, JC.; Ferris, DG.; Lieberman, RW.. "Using acetowhite opacity index for detecting cervical intraepithelial neoplasia.". J Biomed Opt 14 (1): 014020. doi:10.1117/1.3079810. PMID 19256708.
  2. ↑ Sivridis, E.; Karpathiou, G.; Malamou-Mitsi, V.; Giatromanolaki, A. (2010). "Intestinal-type metaplasia in the original squamous epithelium of the cervix.". Eur J Gynaecol Oncol 31 (3): 319-22. PMID 21077478.
  3. ↑ URL: http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html. Accessed on: 9 October 2013.
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