Difference between revisions of "Trophoblast"
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==Intermediate trophoblast== | ==Intermediate trophoblast== | ||
===General=== | ===General=== | ||
* | *Abbreviated: ''IT''. | ||
*Thought to be the cell of origin for:<ref name=pmid11192071>{{cite journal |author=Shih IM, Kurman RJ |title=The pathology of intermediate trophoblastic tumors and tumor-like lesions |journal=Int. J. Gynecol. Pathol. |volume=20 |issue=1 |pages=31–47 |year=2001 |month=January |pmid=11192071 |doi= |url=}}</ref> | *Thought to be the cell of origin for:<ref name=pmid11192071>{{cite journal |author=Shih IM, Kurman RJ |title=The pathology of intermediate trophoblastic tumors and tumor-like lesions |journal=Int. J. Gynecol. Pathol. |volume=20 |issue=1 |pages=31–47 |year=2001 |month=January |pmid=11192071 |doi= |url=}}</ref> | ||
| Line 33: | Line 33: | ||
**Placental site trophoblastic tumor (PSTT). | **Placental site trophoblastic tumor (PSTT). | ||
**Epithelioid trophoblastic tumor (ETT). | **Epithelioid trophoblastic tumor (ETT). | ||
===Subtypes=== | |||
Three subtypes of IT are recognized:<ref name=pmid11192071>{{cite journal |author=Shih IM, Kurman RJ |title=The pathology of intermediate trophoblastic tumors and tumor-like lesions |journal=Int. J. Gynecol. Pathol. |volume=20 |issue=1 |pages=31–47 |year=2001 |month=January |pmid=11192071 |doi= |url=}}</ref> | |||
#Implanation site IT. | |||
#Villous IT. | |||
#Chorionic-type IT. | |||
===Microscopic=== | ===Microscopic=== | ||
Revision as of 04:10, 27 July 2010
Chorionic villi are part of a normal pregnancy. They are derived from the conceptus, i.e. NOT maternal.
Tumours arising from the trophoblast are dealt with in gestational trophoblastic disease.
Chorionic villi 101
- Maternal blood is around villi.
- Fetal blood (nucleated (fetal) RBCs) in the villi.
Basic histology
- Outer layer of villus: syncytiotrophoblasts.
- Beneath syncytiotrophoblast (and closer to fetus) cytotrophoblasts.
Chorionic villi 102
- Syncytiotrophoblasts (eosinophilic cytoplasm with vacuoles (contain hCG), multiple hyperchromatic nuclei).
- Large + many irreg. or lobular hyperchromatic nuclei.
- Eosinophilic vacuolated cytoplasm (contains hCG).
- Closest to mom - covers cytotrophoblast.[1]
- Cytotrophoblasts (polygonal shape, distinct borders, clear cytoplasm, in cords, single nucleus).
- Polygonal shaped cells in cords/masses.
- Distinct cell borders.
- Covered by syncytiobrophoblast[2] - closer to fetus than syncytiotrophoblasts.
- Clear cytoplasm.
- Single uniform nucleus.
Intermediate trophoblast
General
- Abbreviated: IT.
- Thought to be the cell of origin for:[3]
- Exaggerated placental site (EPS).
- Placental site nodule (PSN).
- Placental site trophoblastic tumor (PSTT).
- Epithelioid trophoblastic tumor (ETT).
Subtypes
Three subtypes of IT are recognized:[3]
- Implanation site IT.
- Villous IT.
- Chorionic-type IT.
Microscopic
Features:
- Large cells.
- Eosinophilic cytoplasm.
- May be multi-nucleated.
IHC
Features:[4]
- hPL (human placental lactogen) +ve.
- beta-hCG -ve.
- Keratin +ve.
- EMA +ve in 2nd & 3rd trimester.
Notes:
- Cytotrophoblast and syncytiotrophoblast - keratin +ve.[4]
Age of villi
Young villi
- Do not have blood vessels.
- No syncytial knots.
Old villi
- Blood vessels present and at the periphery of villus - contain nucleated (fetal) RBCs.
- Syncytial knots.
See also
References
- ↑ http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png
- ↑ http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png
- ↑ 3.0 3.1 Shih IM, Kurman RJ (January 2001). "The pathology of intermediate trophoblastic tumors and tumor-like lesions". Int. J. Gynecol. Pathol. 20 (1): 31–47. PMID 11192071.
- ↑ 4.0 4.1 Yeh IT, O'Connor DM, Kurman RJ (May 1990). "Intermediate trophoblast: further immunocytochemical characterization". Mod. Pathol. 3 (3): 282–7. PMID 1694585.
