Difference between revisions of "Choroid plexus carcinoma"
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'''Choroid plexus carcinoma''' is an uncommon [[neuropathology tumour]] and the malignant counter part of [[choroid plexus papilloma]]. | |||
==General== | |||
*Usually pediatric population. | |||
*Malignant counterpart of ''[[choroid plexus papilloma]]''.<ref name=pmid19679976>{{Cite journal | last1 = Singh | first1 = A. | last2 = Vermani | first2 = S. | last3 = Shruti | first3 = S. | title = Choroid plexus carcinoma: report of two cases. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 3 | pages = 405-7 | month = | year = | doi = 10.4103/0377-4929.55009 | PMID = 19679976 }}</ref> | |||
*Poor prognosis - WHO grade III.<ref name=pmid20644273>{{Cite journal | last1 = Menon | first1 = G. | last2 = Nair | first2 = SN. | last3 = Baldawa | first3 = SS. | last4 = Rao | first4 = RB. | last5 = Krishnakumar | first5 = KP. | last6 = Gopalakrishnan | first6 = CV. | title = Choroid plexus tumors: an institutional series of 25 patients. | journal = Neurol India | volume = 58 | issue = 3 | pages = 429-35 | month = | year = | doi = 10.4103/0028-3886.66455 | PMID = 20644273 |URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref> | |||
*Classically posterior fossa. | |||
*Intraventricular mass. | |||
==Microscopic== | |||
Features:<ref name=pmid19679976/> | |||
*Choroid plexus epithelium with [[nuclear pleomorphism]] & high [[NC ratio]]. | |||
*Mitoses. | |||
*Necrosis. | |||
*+/-Brain invasion. | |||
DDx: | |||
*[[Choroid plexus papilloma]]. | |||
*Atypical plexus papilloma - has features intermediate between ''choroid plexus papilloma'' and ''choroid plexus carcinoma''.<ref name=pmid20644273/> | |||
*[[Atypical teratoid/rhabdoid tumour]]. | |||
===Images=== | |||
<gallery> | |||
Image:Choroidplexuscarcinoma.png | CPC. (WC/Martin Hasselblatt) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case198/micro.html Choroid plexus carcinoma - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=pmid20644273/> | |||
*Cytokeratins +ve. | |||
*EMA usu. -ve. | |||
*GFAP -ve (~20% +ve). | |||
*Ki-67 high. | |||
**Useful to diff. from benign counterpart. | |||
*INI1 +ve. | |||
==See also== | |||
*[[Neuropathology tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||
Revision as of 06:08, 10 December 2014
Choroid plexus carcinoma is an uncommon neuropathology tumour and the malignant counter part of choroid plexus papilloma.
General
- Usually pediatric population.
- Malignant counterpart of choroid plexus papilloma.[1]
- Poor prognosis - WHO grade III.[2]
- Classically posterior fossa.
- Intraventricular mass.
Microscopic
Features:[1]
- Choroid plexus epithelium with nuclear pleomorphism & high NC ratio.
- Mitoses.
- Necrosis.
- +/-Brain invasion.
DDx:
- Choroid plexus papilloma.
- Atypical plexus papilloma - has features intermediate between choroid plexus papilloma and choroid plexus carcinoma.[2]
- Atypical teratoid/rhabdoid tumour.
Images
CPC. (WC/Martin Hasselblatt)
www:
IHC
Features:[2]
- Cytokeratins +ve.
- EMA usu. -ve.
- GFAP -ve (~20% +ve).
- Ki-67 high.
- Useful to diff. from benign counterpart.
- INI1 +ve.
See also
References
- ↑ 1.0 1.1 Singh, A.; Vermani, S.; Shruti, S.. "Choroid plexus carcinoma: report of two cases.". Indian J Pathol Microbiol 52 (3): 405-7. doi:10.4103/0377-4929.55009. PMID 19679976.
- ↑ 2.0 2.1 2.2 Menon, G.; Nair, SN.; Baldawa, SS.; Rao, RB.; Krishnakumar, KP.; Gopalakrishnan, CV.. "Choroid plexus tumors: an institutional series of 25 patients.". Neurol India 58 (3): 429-35. doi:10.4103/0028-3886.66455. PMID 20644273.