Difference between revisions of "Gestational trophoblastic disease"

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Gestational trophoblastic disease (view source)

Revision as of 23:31, 1 January 2012

278 bytes added ,  23:31, 1 January 2012
→‎Placental site trophoblastic tumour: tweak, add more refs.
m (→‎Clinical: replace pathconsultddx ref)
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*Malignant counterpart of ''exaggerated placental site'' (abbreviated ''EPS'').
*Malignant counterpart of ''exaggerated placental site'' (abbreviated ''EPS'').
===General===
===General===
====Clinical====
*Raised (serum) beta-hCG - but usually not has high as in choriocarcinoma; in ~70% < 1000 IU/L.<ref name=pmid19552948>{{Cite journal  | last1 = Schmid | first1 = P. | last2 = Nagai | first2 = Y. | last3 = Agarwal | first3 = R. | last4 = Hancock | first4 = B. | last5 = Savage | first5 = PM. | last6 = Sebire | first6 = NJ. | last7 = Lindsay | first7 = I. | last8 = Wells | first8 = M. | last9 = Fisher | first9 = RA. | title = Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study. | journal = Lancet | volume = 374 | issue = 9683 | pages = 48-55 | month = Jul | year = 2009 | doi = 10.1016/S0140-6736(09)60618-8 | PMID = 19552948 }}</ref>
*Derived from ''intermediate trophoblast''.
*Derived from ''intermediate trophoblast''.
*Follows pregnancy.
*Follows pregnancy.
Clinical:
*Raised (serum) beta-hCG - but usually not has high as in [[choriocarcinoma]].
**In ~70% < 1000 IU/L.<ref name=pmid19552948>{{Cite journal  | last1 = Schmid | first1 = P. | last2 = Nagai | first2 = Y. | last3 = Agarwal | first3 = R. | last4 = Hancock | first4 = B. | last5 = Savage | first5 = PM. | last6 = Sebire | first6 = NJ. | last7 = Lindsay | first7 = I. | last8 = Wells | first8 = M. | last9 = Fisher | first9 = RA. | title = Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study. | journal = Lancet | volume = 374 | issue = 9683 | pages = 48-55 | month = Jul | year = 2009 | doi = 10.1016/S0140-6736(09)60618-8 | PMID = 19552948 }}</ref>
**In a series of 55 cases the average beta-hCG was ~700 IU/L.<ref name=pmid16246400>{{Cite journal  | last1 = Baergen | first1 = RN. | last2 = Rutgers | first2 = JL. | last3 = Young | first3 = RH. | last4 = Osann | first4 = K. | last5 = Scully | first5 = RE. | title = Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. | journal = Gynecol Oncol | volume = 100 | issue = 3 | pages = 511-20 | month = Mar | year = 2006 | doi = 10.1016/j.ygyno.2005.08.058 | PMID = 16246400 }}</ref>
*Prognosis dependent on time of diagnosis from last pregnancy.
*Prognosis dependent on time of diagnosis from last pregnancy.
**<48 months good prognosis.<ref name=pmid19552948/>
**<48 months good prognosis.<ref name=pmid19552948/>
====Epidemiology====
*Usually follows a normal pregnancy ~ 75% of cases.<ref name=pstt_pc>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70463-6 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70463-6]. Accessed on: 23 September 2009.</ref>


===Microscopic===
===Microscopic===
Michael
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