Difference between revisions of "NUT carcinoma"
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*[[Carcinoma ex pleomorphic adenoma]]. | *[[Carcinoma ex pleomorphic adenoma]]. | ||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:NUT_midline_carcinoma_-_high_mag.jpg NUT midline carcinoma - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:NUT_midline_carcinoma_-_very_high_mag.jpg NUT midline carcinoma - very high mag. (WC)]. | |||
==Molecular== | ==Molecular== | ||
Revision as of 05:51, 8 February 2013
NUT midline carcinoma, abbreviated NMC, is a super rare tumour of the head and neck. The WHO calls this tumour carcinoma with t(15;19) translocation.[1]
General
- Not specific to any tissue type or organ.[2]
- Defined by mutation in NUT gene on chromosome 15.
- NUT = Nuclear protein in testis.[3]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Case report of a NMC in the parotid gland.[4]
- Head, neck and mediastinum.[5]
- Very poor prognosis.[4]
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Images:
Molecular
- Rearrangement of the NUT gene.[2]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 145. ISBN 978-0781765275.
- ↑ 2.0 2.1 2.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 4.0 4.1 den Bakker, MA.; Beverloo, BH.; van den Heuvel-Eibrink, MM.; Meeuwis, CA.; Tan, LM.; Johnson, LA.; French, CA.; van Leenders, GJ. (Aug 2009). "NUT midline carcinoma of the parotid gland with mesenchymal differentiation.". Am J Surg Pathol 33 (8): 1253-8. doi:10.1097/PAS.0b013e3181abe120. PMID 19561446.
- ↑ 5.0 5.1 5.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749