Difference between revisions of "Stratified mucin-producing intraepithelial lesion of the cervix"

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'''Stratified mucin-producing intraepithelial lesion of the cervix''' is a rare dysplastic lesion of the [[uterine cervix]].
'''Stratified mucin-producing intraepithelial lesion of the cervix''' is a rare dysplastic lesion of the [[uterine cervix]]. It is considered to be an overlap of [[endocervical adenocarcinoma in situ]] and [[squamous intraepithelial lesion]].<ref name=pmid25039487/>


It is abbreviated '''SMILE''' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion).
It is abbreviated '''SMILE''' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion).


==General==
==General==
*Rare ~0.6% of cervix lesions in one series.<ref name=pmid25039487>{{Cite journal  | last1 = Boyle | first1 = DP. | last2 = McCluggage | first2 = WG. | title = Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings. | journal = Histopathology | volume = 66 | issue = 5 | pages = 658-63 | month = Apr | year = 2015 | doi = 10.1111/his.12498 | PMID = 25039487 }}</ref>
*Rare ~0.6% of cervix lesions in one series.<ref name=pmid25039487>{{Cite journal  | last1 = Boyle | first1 = DP. | last2 = McCluggage | first2 = WG. | title = Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings. | journal = Histopathology | volume = 66 | issue = 5 | pages = 658-63 | month = Apr | year = 2015 | doi = 10.1111/his.12498 | PMID = 25039487 }}</ref>
*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/>
*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/>
Management:
*Like [[endocervical AIS]].<ref name=pmid25039487/>


==Microscopic==
==Microscopic==
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*[[HSIL]].
*[[HSIL]].
**Mucin may be present superficially.<ref name=pmid11023104/>
**Mucin may be present superficially.<ref name=pmid11023104/>
*[[Endocervical AIS]].


===Images===
===Images===
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