Difference between revisions of "Medical lung diseases"

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*Hypersensitivity pneumonitis (extrinic allergic alveolitis).
*Hypersensitivity pneumonitis (extrinic allergic alveolitis).


==Diseases with prominent bronchiolization==
==Hypersensitivity pneumonitis==
There are many.
*AKA ''extrinsic allergic alveolitis''
*Exposure to stuffs... e.g. moldy hay - ''Farmer's lung'', atypical mycobacteria - ''hot tub lung''.
*Upper lung predominant disease (???).
 
===Microscopic===
Features:
* Lesions have centrilobular prominence - '''important feature'''. <ref name=pmid16061708/>
** Allergens enter lung through airway which has a centrilobular location.
* Granulomata (not typically seen in UIP) - '''important feature'''.<ref name=pmid16061708>PMID 16061708.</ref>
* Chronic interstitial inflammation consisting primarily of lymphocytes.
* Interstitial fibrosis.
* Air space involvement (alveolitis).
 
Images:
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_intermed_mag.jpg Hypersensitivity pneumonitis - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_high_mag.jpg Hypersensitivity pneumonitis - high mag. (WC)].


==Pulmonary Langerhans cell histiocytosis==
==Pulmonary Langerhans cell histiocytosis==
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**Smoker's macrophages (brown pigmented airspace macrophages).
**Smoker's macrophages (brown pigmented airspace macrophages).
**Chronic inflammatory cells (lymphocytes).
**Chronic inflammatory cells (lymphocytes).
==Hypersensitivity pneumonitis==
*AKA ''extrinsic allergic alveolitis''
*Exposure to stuffs... e.g. moldy hay - ''Farmer's lung'', atypical mycobacteria - ''hot tub lung''.
*Upper lung predominant disease (???).
===Microscopic===
Features:
* Lesions have centrilobular prominence - '''important feature'''. <ref name=pmid16061708/>
** Allergens enter lung through airway which has a centrilobular location.
* Granulomata (not typically seen in UIP) - '''important feature'''.<ref name=pmid16061708>PMID 16061708.</ref>
* Chronic interstitial inflammation consisting primarily of lymphocytes.
* Interstitial fibrosis.
* Air space involvement (alveolitis).
Images:
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_intermed_mag.jpg Hypersensitivity pneumonitis - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_high_mag.jpg Hypersensitivity pneumonitis - high mag. (WC)].
===IHC===
Nodules positive for:
*S-100.
*CD1a.


=Miscellaneous diseases=
=Miscellaneous diseases=
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