Difference between revisions of "Diffuse lung diseases"

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Diffuse lung diseases (view source)

Revision as of 04:23, 31 March 2014

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==Asbestosis==
==Asbestosis==
===General===
{{Main|Asbestosis}}
Definition:
*Interstitial lung disease due to asbestos exposure.<ref name=Ref_PCPBoD8_375>{{Ref PCPBoD8|375}}</ref>
**Important to diagnose... asbestosis = compensation.
 
Conditions associated with asbestos exposure (mnemonic ''PALM''):<ref name=Ref_PCPBoD8_375>{{Ref PCPBoD8|375}}</ref>
*[[Pleural plaques]].
*Asbestosis.
*[[Lung carcinoma]].
*[[Malignant mesothelioma]].
 
 
Possible association with asbestos exposure:
*[[Gestational trophoblastic disease]].<ref name=pmid19900938>{{Cite journal  | last1 = Reid | first1 = A. | last2 = Heyworth | first2 = J. | last3 = de Klerk | first3 = N. | last4 = Musk | first4 = AW. | title = Asbestos exposure and gestational trophoblastic disease: a hypothesis. | journal = Cancer Epidemiol Biomarkers Prev | volume = 18 | issue = 11 | pages = 2895-8 | month = Nov | year = 2009 | doi = 10.1158/1055-9965.EPI-09-0731 | PMID = 19900938 }}</ref>
 
Diagnosis:
*Rests on morphology with special techniques (e.g. polarization)<ref>{{Cite journal  | last1 = Galateau-Salle | first1 = F. | title = [Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]. | journal = Rev Mal Respir | volume = 16 | issue = 6 Pt 2 | pages = 1244-56 | month = Dec | year = 1999 | doi =  | PMID = 10897845 }}</ref> and includes tunneling [[electron microscopy]] (TEM),<ref name=pmid21479897>{{Cite journal  | last1 = Neumann | first1 = V. | last2 = Löseke | first2 = S. | last3 = Tannapfel | first3 = A. | title = Mesothelioma and analysis of tissue fiber content. | journal = Recent Results Cancer Res | volume = 189 | issue =  | pages = 79-95 | month =  | year = 2011 | doi = 10.1007/978-3-642-10862-4_6 | PMID = 21479897 }}</ref> as done at special centres.
**Tissue is typically digested prior to fibre counting.<ref name=pmid20196674>{{Cite journal  | last1 = Roggli | first1 = VL. | last2 = Gibbs | first2 = AR. | last3 = Attanoos | first3 = R. | last4 = Churg | first4 = A. | last5 = Popper | first5 = H. | last6 = Cagle | first6 = P. | last7 = Corrin | first7 = B. | last8 = Franks | first8 = TJ. | last9 = Galateau-Salle | first9 = F. | title = Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. | journal = Arch Pathol Lab Med | volume = 134 | issue = 3 | pages = 462-80 | month = Mar | year = 2010 | doi = 10.1043/1543-2165-134.3.462 | PMID = 20196674 }}</ref>
 
===Microscopic===
Features:<ref name=pmid20196674/>
#Interstitial fibrosis - similar to [[usual interstitial pneumonia]] (UIP).
#''Ferruginous bodies'' - '''key feature'''.
#*Segmented twirling baton with long slender fibre within.
 
====Images====
<gallery>
Image:Ferruginous_body.jpg | Ferruginous bodies. (WC)
Image:Asbestosis_high_mag.jpg | Asbestosis. (WC)
</gallery>


==Non-specific interstitial pneumonia==
==Non-specific interstitial pneumonia==
Michael
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