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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 13:26, 2 May 2012
, 13:26, 2 May 2012wikify
(→Placental site trophoblastic tumour: +IHC, tweak) |
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**Classically said to be produced by syncytiotrophoblasts.<ref name=pmid20735820>{{Cite journal | last1 = Cole | first1 = LA. | title = Biological functions of hCG and hCG-related molecules. | journal = Reprod Biol Endocrinol | volume = 8 | issue = | pages = 102 | month = | year = 2010 | doi = 10.1186/1477-7827-8-102 | PMID = 20735820 | PMC = 2936313 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936313/ }} | **Classically said to be produced by syncytiotrophoblasts.<ref name=pmid20735820>{{Cite journal | last1 = Cole | first1 = LA. | title = Biological functions of hCG and hCG-related molecules. | journal = Reprod Biol Endocrinol | volume = 8 | issue = | pages = 102 | month = | year = 2010 | doi = 10.1186/1477-7827-8-102 | PMID = 20735820 | PMC = 2936313 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936313/ }} | ||
</ref> | </ref> | ||
*** | ***[[Cytotrophoblast]]s also produce some.<ref name=pmid20735820/><ref name=pmid12242037>{{Cite journal | last1 = Kovalevskaya | first1 = G. | last2 = Genbacev | first2 = O. | last3 = Fisher | first3 = SJ. | last4 = Caceres | first4 = E. | last5 = O'Connor | first5 = JF. | title = Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. | journal = Mol Cell Endocrinol | volume = 194 | issue = 1-2 | pages = 147-55 | month = Aug | year = 2002 | doi = | PMID = 12242037 }}</ref> | ||
==Hydatidiform moles== | ==Hydatidiform moles== | ||
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***Contain fluid in the centre, i.e. are "hydropic". | ***Contain fluid in the centre, i.e. are "hydropic". | ||
**Villi with cytotrophoblastic inclusions. | **Villi with cytotrophoblastic inclusions. | ||
***Cytotrophoblast in the core of a villus (normally it is only at the surface of the villus). | ***[[Cytotrophoblast]] in the core of a villus (normally it is only at the surface of the villus). | ||
*May have fetal parts, such as nucleated RBCs. | *May have fetal parts, such as nucleated RBCs. | ||
*Trophoblastic proliferation. | *Trophoblastic proliferation. | ||
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|- | |- | ||
| [[Choriocarcinoma]] | | [[Choriocarcinoma]] | ||
| polygonal cells with clear cytoplasm ( | | polygonal cells with clear cytoplasm ([[cytotrophoblast]]s) | ||
| multinucleated cells with smudged nuclei ( | | multinucleated cells with smudged nuclei ([[syncytiotrophoblast]]s), '''no''' [[chorionic villi]] | ||
| beta-hCG +ve, p63 +ve | | beta-hCG +ve, p63 +ve | ||
| [[invasive hydatidiform mole]], [[PSTT]] | | [[invasive hydatidiform mole]], [[PSTT]] | ||