Difference between revisions of "Langerhans cell histiocytosis"
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid16295427/> | ||
*Langerhans cells histiocytes - '''key feature'''. | *Langerhans cells histiocytes - '''key feature'''. | ||
**Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | **Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | ||
***Nucleus may look like a "[[coffee bean nucleus|coffee bean]]", i.e. have nuclear grooves (similar to those in [[papillary thyroid carcinoma]]) -- appearance dependent on the rotation of the nucleus.<ref>BN. 15 March 2011.</ref> | ***Nucleus may look like a "[[coffee bean nucleus|coffee bean]]", i.e. have nuclear grooves (similar to those in [[papillary thyroid carcinoma]]) -- appearance dependent on the rotation of the nucleus.<ref>BN. 15 March 2011.</ref> May be called "buttock cells". | ||
***Chromatin pattern: fine granular, light gray. | ***Chromatin pattern: fine granular, light gray. | ||
*+/-Eosinophils - often prominent. | *+/-Eosinophils - often prominent. | ||
*+/-Fibrosis - common. | |||
*+/-Other inflammatory cells - neutrophils, plasma cells (uncommon). | |||
*+/-Multinucleated giant cells - uncommon. | |||
Images: | Images: | ||