Difference between revisions of "Uterine cervix"

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 See: [http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf]
-===Squamous metaplasia===
+===Squamous metaplasia of the uterine cervix===
-Squamous metaplasia is a response to inflammation...
+====General====
+*Benign process: columnar cells -> squamoid cells.
+**Biologic response to irritation and/or inflammation.
+====Microscopic====
+Features:
 * Nuclei are uniform size and round.
-* Intercellular bridges are often seen/edema is often seen.
+** Nucleoli present.
-* Uniform cell spacing, i.e. NO crowding.
+* +/-Intercellular bridges (due to edema) - common.
-* NEGATIVES:
+* Uniform cell spacing, i.e. no crowding.
-** No mitoses (think cancer/CIN if you see 'em).
-** Usually no hyperchromatism (think cancer/CIN if you see it).
+Negatives:
+* No mitoses (think cancer/CIN if you see 'em).
+* Usually no hyperchromatism (think cancer/CIN if you see it).
 Notes:
-*It is possible to confuse CIN III with squamous metaplasia.
+*NC ratio high - possible to confuse CIN III.
+DDx:
+*[[CIN III]].
+*[[Squamous cell carcinoma of the uterine cervix]].
 ===IHC===

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