Difference between revisions of "Uterine cervix"

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===Histologic changes in CIN I, CIN II and CIN III===

*CIN I = cytoplasmic halos (koilocytic atypia), atypical cells close to basement membrane only.

**3:1 ~~enlargement of~~ nucleus ~~vs.~~ normal.~~<ref>[need ref]</ref>~~

**Nuclear enlargement -- >=3:1 enlarged nucleus:normal nucleus.

**Binucleation may be seen (cytopathic effect of HPV).<ref>~~[need ref]~~</ref>

**Binucleation may be seen (cytopathic effect of HPV).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref>

*CIN II = increased nuclear-cytoplasmic ratio, loss of polarity, incr. mitoses, hyperchromasia.

**If there are large nuclei... you should seen 'em on low power, i.e. 25x.

Difference between revisions of "Uterine cervix"

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 ===Histologic changes in CIN I, CIN II and CIN III===
 *CIN I = cytoplasmic halos (koilocytic atypia), atypical cells close to basement membrane only.
-**3:1 enlargement of nucleus vs. normal.<ref>[need ref]</ref>
+**Nuclear enlargement -- >=3:1 enlarged nucleus:normal nucleus.
-**Binucleation may be seen (cytopathic effect of HPV).<ref>[need ref]</ref>
+**Binucleation may be seen (cytopathic effect of HPV).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref>
 *CIN II = increased nuclear-cytoplasmic ratio, loss of polarity, incr. mitoses, hyperchromasia.
 **If there are large nuclei... you should seen 'em on low power, i.e. 25x.