Difference between revisions of "Wilson's disease"

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770 bytes added ,  19:17, 9 January 2017
→‎Microscopic: added a case
(→‎Microscopic: added a case)
 
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*[[Steatosis of the liver|Steatosis]].
*[[Steatosis of the liver|Steatosis]].
*Portal fibrosis.
*Portal fibrosis.
{|
 
[[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments  (40X).]]
A. [[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments  (40X).]]<br>
[[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]  (200X).]]
B. [[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]  (200X).]]<br>
<br>
C. [[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]<br>
[[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
D. [[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]<br>
[[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]
Wilson’s disease, pre-cirrhotic. A. Inflamed & relatively unaffected segments. B. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]. C. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli. D. Trichrome shows periportal & sinusoidal fibrosis.
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Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).
[[File:4 38555059990939 sl 1.png|Wilson’s disease with cirrhosis]]
[[File:4 38555059990939 sl 2.png|Wilson’s disease with cirrhosis]]
[[File:4 38555059990939 sl 3.png|Wilson’s disease with cirrhosis]]
[[File:4 38555059990939 sl 4.png|Wilson’s disease with cirrhosis]]
[[File:4 38555059990939 sl 5.png|Wilson’s disease with cirrhosis]] <br>
Wilson’s disease with cirrhosis in a 22 year old woman. A. Nodules show steatosis without definite triads.  B. Trichrome shows minute fibrous bound nodules in this case. C. Reticulin shows extensive regeneration (2-3 nuclei thick cords with lack of direction) with nodule formation. D. Bridge with extensive proliferated bile ductules and acute and chronic inflammatory cells. E. Ballooning degeneration with Mallory bodies.


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