Difference between revisions of "Gallbladder cholesterolosis"

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#redirect [[Gallbladder#Cholesterolosis]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Gallbladder_cholesterolosis_intermed_mag_cropped.jpg
| Width      =
| Caption    = Gallbladder cholesterolosis. [[H&E stain]].
| Micro      = abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia
| Subtypes  =
| LMDDx      = [[cholesterol polyp of gallbladder]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = gallbladder mucosa with strawberry-like texture
| Grossing  =
| Site      = [[gallbladder]]
| Assdx      = [[chronic cholecystitis]], [[obesity]], [[cholelithiasis]]
| Syndromes  =
| Clinicalhx = biliary colic - due to chronic cholecystitis
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
}}
'''Gallbladder cholesterolosis''', also known simply as '''cholesterolosis''', is a common [[gallbladder]] pathology associated with [[chronic cholecystitis]].


Informally, gallbladder cholesterolosis is known as ''strawberry gallbladder''.
==General==
*Common in [[chronic cholecystitis]].
*Seen in ~13% of cases in a large series of 23,304 gallbladders.<ref name=pmid21043073>{{Cite journal  | last1 = Roa | first1 = I. | last2 = de Aretxabala | first2 = X. | last3 = Ibacache | first3 = G. | last4 = Muñoz | first4 = S. | title = [Association between cholesterolosis and gallbladder cancer]. | journal = Rev Med Chil | volume = 138 | issue = 7 | pages = 804-8 | month = Jul | year = 2010 | doi =  | PMID = 21043073 }}</ref>
**Slightly more common in women than men (14% of cases in women versus 10% of cases in men).
*Less likely to be associated with cancer than gallbladders without cholesterolosis; relative risk of cancer in non-cholesterolosis gallbladders 9.2.<ref name=pmid21043073/>
*Associated with yellow [[gallstones]] (cholesterol type gallstones).
==Gross==
Features:
*Mucosa has strawberry-like appearance.
**The similarity is in the surface texture.
**The colour (yellow) is not strawberry-like.
===Image===
<gallery>
Image:Cholesterolosis_of_the_Gallbladder.jpg | Gallbladder cholesterolosis. (WC/euthman)
</gallery>
==Microscopic==
Features:
*Numerous foamy macrophages in the lamina propria.
*+/-Papillary hyperplasia.<ref name=pmid7990683>{{Cite journal  | last1 = Celoria | first1 = GC. | last2 = Rodríguez Otero | first2 = JC. | last3 = Proske | first3 = SA. | last4 = Vallilengua | first4 = C. | title = Papillary hyperplasia and cholesterolosis of the gallbladder. | journal = Medicina (B Aires) | volume = 54 | issue = 1 | pages = 31-4 | month =  | year = 1994 | doi =  | PMID = 7990683 }}</ref>
DDx:
*[[Cholesterol polyp of gallbladder]] - polypoid shape.
===Image===
<gallery>
Image:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg | Cholesterolosis - intermed. mag. (WC)
Image:Gallbladder_cholesterolosis_micro.jpg | Cholesterolosis. (WC)
</gallery>
www:
*[http://www.surgpath4u.com/caseviewer.php?case_no=523 Papillary hyperplasia (surgpath4u.com)].
==Sign out==
<pre>
GALLBLADDER, CHOLECYSTECTOMY:
- CHRONIC CHOLECYSTITIS WITH CHOLESTEROLOSIS.
- CHOLELITHIASIS.
</pre>
<pre>
GALLBLADDER, CHOLECYSTECTOMY:
- CHRONIC CHOLECYSTITIS WITH FOCAL FOAMY MACROPHAGES IN LAMINA PROPRIA.
- CHOLELITHIASIS.
</pre>
==See also==
*[[Chronic cholecystitis]].
*[[Gallbladder]].
==References==
{{Reflist|2}}
[[Category:Gallbladder]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 05:02, 1 June 2016

Gallbladder cholesterolosis
Diagnosis in short

Gallbladder cholesterolosis. H&E stain.
LM abundant foamy macrophages in the lamina propria, +/-papillary hyperplasia
LM DDx cholesterol polyp of gallbladder
Gross gallbladder mucosa with strawberry-like texture
Site gallbladder
Associated Dx chronic cholecystitis, obesity, cholelithiasis
Clinical history biliary colic - due to chronic cholecystitis
Prevalence common
Prognosis benign

Gallbladder cholesterolosis, also known simply as cholesterolosis, is a common gallbladder pathology associated with chronic cholecystitis.

Informally, gallbladder cholesterolosis is known as strawberry gallbladder.

General

  • Common in chronic cholecystitis.
  • Seen in ~13% of cases in a large series of 23,304 gallbladders.[1]
    • Slightly more common in women than men (14% of cases in women versus 10% of cases in men).
  • Less likely to be associated with cancer than gallbladders without cholesterolosis; relative risk of cancer in non-cholesterolosis gallbladders 9.2.[1]
  • Associated with yellow gallstones (cholesterol type gallstones).

Gross

Features:

  • Mucosa has strawberry-like appearance.
    • The similarity is in the surface texture.
    • The colour (yellow) is not strawberry-like.

Image

  • Gallbladder cholesterolosis. (WC/euthman)

Microscopic

Features:

  • Numerous foamy macrophages in the lamina propria.
  • +/-Papillary hyperplasia.[2]

DDx:

Image

  • Cholesterolosis - intermed. mag. (WC)

  • Cholesterolosis. (WC)

www:

Sign out

GALLBLADDER, CHOLECYSTECTOMY:
- CHRONIC CHOLECYSTITIS WITH CHOLESTEROLOSIS.
- CHOLELITHIASIS.

GALLBLADDER, CHOLECYSTECTOMY:
- CHRONIC CHOLECYSTITIS WITH FOCAL FOAMY MACROPHAGES IN LAMINA PROPRIA.
- CHOLELITHIASIS.

See also

References

  1. ↑ 1.0 1.1 Roa, I.; de Aretxabala, X.; Ibacache, G.; Muñoz, S. (Jul 2010). "[Association between cholesterolosis and gallbladder cancer].". Rev Med Chil 138 (7): 804-8. PMID 21043073.
  2. ↑ Celoria, GC.; Rodríguez Otero, JC.; Proske, SA.; Vallilengua, C. (1994). "Papillary hyperplasia and cholesterolosis of the gallbladder.". Medicina (B Aires) 54 (1): 31-4. PMID 7990683.
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