Difference between revisions of "Chronic sialadenitis"

Latest revision as of 18:28, 8 September 2020

Chronic sialadenitis is a chronic inflammatory process involving a salivary gland.

Chronic sailolithiasis redirects here. Sialadenitis redirects here. Chronic sclerosing sialadenitis (also known as Küttner tumour^[1]) redirects here.

General

Occasionally associated with malignancy, e.g. adenoid cystic carcinoma.^[2]

Etiology:^[3]

Infection.
Autoimmune (e.g. Sjögren syndrome, systemic lupus erythematosus).
Other.

Associations:

Smoking.^[4] (???)

Gross

Features:

Typical location: submandibular salivary gland.
Salivary gland swelling.^[2]

Microscopic

Features:

Non-neoplastic mononuclear inflammatory infiltrate (lymphocytes, plasma cells).
Fibrosis.
+/-Calcifications.

Note:

If the infiltrate is predominantly lymphocytes Sjögren's is a possibility, and reporting a Focus score should be considered.

DDx:

Lymphoma - especially MALT lymphoma.^[5]
IgG4-related sialadenitis.^[6]

Image

Chronic sialadenitis. (WC/Nephron)

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SUBMANDIBULAR GLAND, RIGHT, EXCISION:
- CHRONIC SIALOADENITIS.
- SIALOLITHIASIS.
- TWO BENIGN LYMPH NODES.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show submandibular salivary gland with a mild patchy mixed mononuclear cell infiltrate, fibrosis and a large benign calcification. No zonal necrosis is identified. Significant nuclear atypia is not identified.

Alternate

The sections show a salivary gland with a patchy mixed mononuclear cell infiltrate and fibrosis. Significant nuclear atypia is not identified. Plasma cells are not prominent. Germinal centres are present.

References

↑ Keidar E, Shermetaro J, Kwartowitz G (June 2020). "Pediatric Parotid Chronic Sclerosing Sialadenitis in an African-American Female: A Rare Case and Review of the Literature". Cureus 12 (6): e8846. doi:10.7759/cureus.8846. PMC 7386075. PMID 32754389. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386075/.
↑ ^2.0 ^2.1 Hasegawa M, Cheng J, Maruyama S, et al. (June 2011). "Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background". Int J Oral Maxillofac Surg 40 (6): 647–50. doi:10.1016/j.ijom.2010.11.009. PMID 21159490.
↑ URL: http://emedicine.medscape.com/article/882358-overviewhttp://emedicine.medscape.com/article/882358-overview. Accessed on: 10 January 2011.
↑ Eliasson L, Heyden G, Landahl S, Steen B (March 1991). "Effects of tobacco and diuretics on human palatal salivary glands". J. Oral Pathol. Med. 20 (3): 126–9. PMID 2037973.
↑ Beasley, MJ. (Apr 2012). "Lymphoma of the Thyroid and Head and Neck.". Clin Oncol (R Coll Radiol). doi:10.1016/j.clon.2012.02.010. PMID 22475637.
↑ Thompson LDR (November 2019). "IgG4-Related Sialadenitis". Ear Nose Throat J: 145561319890153. doi:10.1177/0145561319890153. PMID 31760789.

[pmid32754389-1] Keidar E, Shermetaro J, Kwartowitz G (June 2020). "Pediatric Parotid Chronic Sclerosing Sialadenitis in an African-American Female: A Rare Case and Review of the Literature". Cureus 12 (6): e8846. doi:10.7759/cureus.8846. PMC 7386075. PMID 32754389. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386075/.

[pmid21159490-2] 2.0 ^2.1 Hasegawa M, Cheng J, Maruyama S, et al. (June 2011). "Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background". Int J Oral Maxillofac Surg 40 (6): 647–50. doi:10.1016/j.ijom.2010.11.009. PMID 21159490.

[3] URL: http://emedicine.medscape.com/article/882358-overviewhttp://emedicine.medscape.com/article/882358-overview. Accessed on: 10 January 2011.

[pmid2037973-4] Eliasson L, Heyden G, Landahl S, Steen B (March 1991). "Effects of tobacco and diuretics on human palatal salivary glands". J. Oral Pathol. Med. 20 (3): 126–9. PMID 2037973.

[pmid22475637-5] Beasley, MJ. (Apr 2012). "Lymphoma of the Thyroid and Head and Neck.". Clin Oncol (R Coll Radiol). doi:10.1016/j.clon.2012.02.010. PMID 22475637.

[pmid31760789-6] Thompson LDR (November 2019). "IgG4-Related Sialadenitis". Ear Nose Throat J: 145561319890153. doi:10.1177/0145561319890153. PMID 31760789.

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@@ Line 1: / Line 1: @@
-#redirect [[Salivary glands#Chronic sialadenitis]]
+'''Chronic sialadenitis''' is a chronic inflammatory process involving a [[salivary glands|salivary gland]].
+'''Chronic sailolithiasis''' redirects here. '''Sialadenitis''' redirects here.
+'''Chronic sclerosing sialadenitis''' (also known as '''Küttner tumour'''<ref name=pmid32754389>{{cite journal |authors=Keidar E, Shermetaro J, Kwartowitz G |title=Pediatric Parotid Chronic Sclerosing Sialadenitis in an African-American Female: A Rare Case and Review of the Literature |journal=Cureus |volume=12 |issue=6 |pages=e8846 |date=June 2020 |pmid=32754389 |pmc=7386075 |doi=10.7759/cureus.8846 |url=}}</ref>) redirects here.
+==General==
+*Occasionally associated with malignancy, e.g. [[adenoid cystic carcinoma]].<ref name=pmid21159490>{{cite journal |author=Hasegawa M, Cheng J, Maruyama S, ''et al.'' |title=Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background |journal=Int J Oral Maxillofac Surg |volume=40 |issue=6 |pages=647–50 |year=2011 |month=June |pmid=21159490 |doi=10.1016/j.ijom.2010.11.009 |url=}}</ref>
+Etiology:<ref>URL: [http://emedicine.medscape.com/article/882358-overview http://emedicine.medscape.com/article/882358-overviewhttp://emedicine.medscape.com/article/882358-overview]. Accessed on: 10 January 2011.</ref>
+*Infection.
+*Autoimmune (e.g. [[Sjögren syndrome]], [[systemic lupus erythematosus]]).
+*Other.
+Associations:
+*[[Smoking]].<ref name=pmid2037973>{{cite journal |author=Eliasson L, Heyden G, Landahl S, Steen B |title=Effects of tobacco and diuretics on human palatal salivary glands |journal=J. Oral Pathol. Med. |volume=20 |issue=3 |pages=126–9 |year=1991 |month=March |pmid=2037973 |doi= |url=}}</ref> (???)
+==Gross==
+Features:
+*Typical location: submandibular salivary gland.
+*Salivary gland swelling.<ref name=pmid21159490/>
+==Microscopic==
+Features:
+*Non-neoplastic mononuclear inflammatory infiltrate (lymphocytes, [[plasma cell]]s).
+*Fibrosis.
+*+/-Calcifications.
+Note:
+*If the infiltrate is predominantly lymphocytes Sjögren's is a possibility, and reporting a ''[[Focus score]]'' should be considered.
+DDx:
+*[[Lymphoma]] - especially [[MALT lymphoma]].<ref name=pmid22475637>{{Cite journal  | last1 = Beasley | first1 = MJ. | title = Lymphoma of the Thyroid and Head and Neck. | journal = Clin Oncol (R Coll Radiol) | volume =  | issue =  | pages =  | month = Apr | year = 2012 | doi = 10.1016/j.clon.2012.02.010 | PMID = 22475637 }}</ref>
+*[[IgG4-related systemic diseases|IgG4-related sialadenitis]].<ref name=pmid31760789>{{cite journal |authors=Thompson LDR |title=IgG4-Related Sialadenitis |journal=Ear Nose Throat J |volume= |issue= |pages=145561319890153 |date=November 2019 |pmid=31760789 |doi=10.1177/0145561319890153 |url=}}</ref>
+===Image===
+<gallery>
+Image:Chronic_sialadenitis.jpg | Chronic sialadenitis. (WC/Nephron)
+</gallery>
+==Sign out==
+<pre>
+SUBMANDIBULAR GLAND, RIGHT, EXCISION:
+- CHRONIC SIALOADENITIS.
+- SIALOLITHIASIS.
+- TWO BENIGN LYMPH NODES.
+- NEGATIVE FOR MALIGNANCY.
+</pre>
+====Micro====
+The sections show submandibular salivary gland with a mild patchy mixed mononuclear cell
+infiltrate, fibrosis and a large benign calcification. No zonal necrosis is identified.
+Significant nuclear atypia is not identified.
+=====Alternate=====
+The sections show a salivary gland with a patchy mixed mononuclear cell infiltrate and fibrosis. Significant nuclear atypia is not identified. Plasma cells are not prominent. Germinal centres are present.
+==See also==
+*[[Salivary gland]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Salivary gland]]