Difference between revisions of "Adenomyoepithelioma"

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#redirect [[Breast_pathology#Adenomyoepithelioma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Adenomyoepithelioma - very high mag.jpg
| Width      =
| Caption    = Adenomyoepithelioma. [[H&E stain]].
| Synonyms  =
| Micro      = glandular architecture with: (1) identifiable myoepithelial cells with clear cytoplasm, (2) eosinophilic cuboidal epithelial cells; eosinophilic basement membrane material between glands
| Subtypes  =
| LMDDx      = [[invasive ductal carcinoma of the breast|invasive ductal carcinoma]], mammary [[pleomorphic adenoma]], ductal adenoma, [[tubular adenoma of the breast]], [[sclerosing adenosis]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[breast]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign, occasionally malignant
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Adenomyoepithelioma''' is an uncommon pathology of the [[breast]]. It is usually benign.
 
==General==
*Rare lesion consisting of epithelial and myoepithelial elements.
**May occur in other sites, e.g. tonsil.<ref name=pmid20356364>{{Cite journal  | last1 = Ren | first1 = J. | last2 = Song | first2 = L. | last3 = Dang | first3 = Q. | last4 = Zhang | first4 = X. | last5 = Jiang | first5 = SW. | last6 = Zhang | first6 = G. | last7 = Wang | first7 = N. | last8 = Liu | first8 = Z. | last9 = Wang | first9 = J. | title = Primary adenomyoepithelioma of tonsil. | journal = Head Neck Oncol | volume = 2 | issue =  | pages = 7 | month =  | year = 2010 | doi = 10.1186/1758-3284-2-7 | PMID = 20356364 }}</ref>
*May be benign or malignant.<ref name=pmid12591699>{{Cite journal  | last1 = Howlett | first1 = DC. | last2 = Mason | first2 = CH. | last3 = Biswas | first3 = S. | last4 = Sangle | first4 = PD. | last5 = Rubin | first5 = G. | last6 = Allan | first6 = SM. | title = Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology. | journal = AJR Am J Roentgenol | volume = 180 | issue = 3 | pages = 799-803 | month = Mar | year = 2003 | doi =  | PMID = 12591699 | url=http://www.ajronline.org/content/180/3/799.full}}</ref><ref name=pmid19480267>{{Cite journal  | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Vasilakaki | first2 = T. | last3 = Grammatoglou | first3 = X. | last4 = Petrakopoulou | first4 = N. | last5 = Nikolaidou | first5 = ME. | last6 = Glava | first6 = C. | title = Malignant adenomyoepithelioma of the breast--case report. | journal = Eur J Gynaecol Oncol | volume = 30 | issue = 2 | pages = 234-6 | month =  | year = 2009 | doi =  | PMID = 19480267 }}</ref>
 
Note:
*Possibly the same tumour as [[epithelial-myoepithelial carcinoma]] of the [[salivary gland]].<ref name=pmid9769134>{{Cite journal  | last1 = Seifert | first1 = G. | title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? | journal = Virchows Arch | volume = 433 | issue = 3 | pages = 285-8 | month = Sep | year = 1998 | doi =  | PMID = 9769134 }}</ref>
 
==Microscopic==
Features:<ref>URL: [http://www.webpathology.com/image.asp?n=1&Case=322 http://www.webpathology.com/image.asp?n=1&Case=322]. Accessed on: 16 August 2011.</ref>
*Well-circumscribed.
*Glandular architecture with:
**Easily identifiable myoepithelial cells - with clear cytoplasm - '''key feature'''.
**Eosinophilic cuboidal epithelial cells.
*Eosinophilic basement membrane material between glands.
 
DDx:
*[[Invasive ductal carcinoma of the breast]] (on core biopsy).
*Mammary pleomorphic adenoma.
*Ductal adenoma.
*[[Tubular adenoma of the breast]] - does not have a prominent (clear) myoepithelial component.
*[[Sclerosing adenosis]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref>
 
===Images===
<gallery>
Image:Adenomyoepithelioma_-_low_mag.jpg | Adenomyoepithelioma - low mag. (WC/Nephron)
Image:Adenomyoepithelioma_-_intermed_mag.jpg | Adenomyoepithelioma - intermed. mag. (WC/Nephron)
Image:Adenomyoepithelioma_-_high_mag.jpg | Adenomyoepithelioma - high mag. (WC/Nephron)
Image:Adenomyoepithelioma_-_very_high_mag.jpg | Adenomyoepithelioma - very high mag. (WC/Nephron)
</gallery>
 
www:
*[http://www.webpathology.com/image.asp?n=1&Case=322 Adenomyoepithelioma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=4&Case=322 Adenomyoepithelioma - high mag. (webpathology.com)].
 
==See also==
*[[Breast pathology]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Breast pathology]]

Latest revision as of 20:24, 16 February 2014

Adenomyoepithelioma
Diagnosis in short

Adenomyoepithelioma. H&E stain.
LM glandular architecture with: (1) identifiable myoepithelial cells with clear cytoplasm, (2) eosinophilic cuboidal epithelial cells; eosinophilic basement membrane material between glands
LM DDx invasive ductal carcinoma, mammary pleomorphic adenoma, ductal adenoma, tubular adenoma of the breast, sclerosing adenosis
Site breast
Prevalence uncommon
Prognosis benign, occasionally malignant

Adenomyoepithelioma is an uncommon pathology of the breast. It is usually benign.

General

  • Rare lesion consisting of epithelial and myoepithelial elements.
    • May occur in other sites, e.g. tonsil.[1]
  • May be benign or malignant.[2][3]

Note:

Microscopic

Features:[5]

  • Well-circumscribed.
  • Glandular architecture with:
    • Easily identifiable myoepithelial cells - with clear cytoplasm - key feature.
    • Eosinophilic cuboidal epithelial cells.
  • Eosinophilic basement membrane material between glands.

DDx:

Images

  • Adenomyoepithelioma - low mag. (WC/Nephron)

  • Adenomyoepithelioma - intermed. mag. (WC/Nephron)

  • Adenomyoepithelioma - high mag. (WC/Nephron)

  • Adenomyoepithelioma - very high mag. (WC/Nephron)

www:

See also

References

  1. ↑ Ren, J.; Song, L.; Dang, Q.; Zhang, X.; Jiang, SW.; Zhang, G.; Wang, N.; Liu, Z. et al. (2010). "Primary adenomyoepithelioma of tonsil.". Head Neck Oncol 2: 7. doi:10.1186/1758-3284-2-7. PMID 20356364.
  2. ↑ Howlett, DC.; Mason, CH.; Biswas, S.; Sangle, PD.; Rubin, G.; Allan, SM. (Mar 2003). "Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology.". AJR Am J Roentgenol 180 (3): 799-803. PMID 12591699. http://www.ajronline.org/content/180/3/799.full.
  3. ↑ Zizi-Sermpetzoglou, A.; Vasilakaki, T.; Grammatoglou, X.; Petrakopoulou, N.; Nikolaidou, ME.; Glava, C. (2009). "Malignant adenomyoepithelioma of the breast--case report.". Eur J Gynaecol Oncol 30 (2): 234-6. PMID 19480267.
  4. ↑ Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
  5. ↑ URL: http://www.webpathology.com/image.asp?n=1&Case=322. Accessed on: 16 August 2011.
  6. ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.
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