Difference between revisions of "Progressive transformation of germinal centers"

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'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare condition seen in [[lymph nodes]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg
| Width      =
| Caption    = PTGC. [[H&E stain]].
| Micro      = follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone
| Subtypes  =
| LMDDx      = [[nodular lymphocyte predominant Hodgkin lymphoma]], other lymphomas
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[lymph node]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = lymphadenopathy
| Symptoms  = asymptomatic
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = [[lymph node metastasis]], [[lymphoma]]
}}
'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]].


==General==
==General==
*Benign.
*Benign.
*Classically in younger patients.
*Classically in younger patients.
*Associated with nodular lymphocyte predominant [[Hodgkin's lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref>
*Associated with [[nodular lymphocyte predominant Hodgkin lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref>


Clinical:
Clinical:
Line 16: Line 45:
**Expanded mantle zone.
**Expanded mantle zone.


Images:
===Images===
*[http://commons.wikimedia.org/wiki/File:Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg PTGCs - very low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Progressive_transformation_of_germinal_centres_-1-_low_mag.jpg PTGCs - low mag. (WC)].
Image:Progressive transformation of germinal centres -1- low mag.jpg| PTGCs - low mag. (WC)
Image:Progressive transformation of germinal centres -1- intermed mag.jpg| PTGCs - intermed. mag. (WC)
</gallery>
<gallery>
Image:Progressive transformation of germinal centers -2- very low mag.jpg| PTGCs - very low mag. (WC)
Image:Progressive transformation of germinal centers -2- low mag.jpg| PTGCs - low mag. (WC)
Image:Progressive transformation of germinal centers -2- intermed mag.jpg| PTGCs - intermed. mag. (WC)
</gallery>


==See also==
==See also==
*[[Lymph node pathology]].
*[[Lymph node pathology]].
*[[Lymph node]].
*[[Haematopathology]].


==References==
==References==
{{Reflist|2}}
{{Reflist|1}}
 
==Additional reading==
*{{cite journal |author=Hansmann ML, Fellbaum C, Hui PK, Moubayed P |title=Progressive transformation of germinal centers with and without association to Hodgkin's disease |journal=Am. J. Clin. Pathol. |volume=93 |issue=2 |pages=219–26 |year=1990 |month=February |pmid=2405631 |doi= |url=}}
*{{cite journal |author=Kojima M, Nakamura S, Motoori T, ''et al.'' |title=Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients |journal=Int. J. Surg. Pathol. |volume=11 |issue=2 |pages=101–7 |year=2003 |month=April |pmid=12754626 |doi= |url=}}


[[Category:Lymph node pathology]]
[[Category:Lymph node pathology]]
[[Category:Diagnosis]]

Latest revision as of 04:22, 5 September 2013

Progressive transformation of germinal centers
Diagnosis in short

PTGC. H&E stain.
LM follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone
LM DDx nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas
Site lymph node
Signs lymphadenopathy
Symptoms asymptomatic
Prevalence very rare
Clin. DDx lymph node metastasis, lymphoma

Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.

General

Clinical:

  • Asymptomatic lymphadenopathy.

Microscopic

Features:

  • Follicular hyperplasia (many follicles).
  • Focally large germinal centers with:
    • Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
    • Expanded mantle zone.

Images

  • PTGCs - low mag. (WC)

  • PTGCs - intermed. mag. (WC)

  • PTGCs - very low mag. (WC)

  • PTGCs - low mag. (WC)

  • PTGCs - intermed. mag. (WC)

See also

References

  1. ↑ 1.0 1.1 Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC (2002). "Progressive transformation of germinal centers. Report of 2 cases and review of the literature". Acta Haematol. 108 (1): 33–8. PMID 12145465.

Additional reading

  • Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
  • Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.
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