Difference between revisions of "Myopericytoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Myopericytoma_-_high_mag.jpg
| Width      =
| Caption    = Myopericytoma. [[H&E stain]].
| Micro      = fascicular pattern (may be subtle) with compressed blood vessels (often thin walled & branching), increased peri-vascular cellularity; high cellularity; small bland unequally spaced epithelioid/spindle cells with moderate eosinophilic cytoplasm
| Subtypes  =
| LMDDx      = [[solitary fibrous tumour]], [[vascular tumours]]
| Stains    =
| IHC        = SMA +ve, H-caldesmon +ve, CD34 +ve (focal), EMA -ve, AE1/AE3 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[soft tissue]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
}}
'''Myopericytoma''', also '''glomangiopericytoma''', is a rare perivascular [[soft tissue lesions|soft tissue tumour]].  
'''Myopericytoma''', also '''glomangiopericytoma''', is a rare perivascular [[soft tissue lesions|soft tissue tumour]].  


==General==
==General==
*Usu. benign.
*Usually benign.
*Typically in the distal extremities.<ref name=pmid21111282>{{cite journal |author=Zidane A, Arsalane A, Harkat A, ''et al.'' |title=[Myopericytoma: an uncommon chest wall tumor] |language=French |journal=Rev Mal Respir |volume=27 |issue=9 |pages=1089–91 |year=2010 |month=November |pmid=21111282 |doi=10.1016/j.rmr.2010.09.017 |url=}}</ref>
*Typically in the distal extremities.<ref name=pmid21111282>{{cite journal |author=Zidane A, Arsalane A, Harkat A, ''et al.'' |title=[Myopericytoma: an uncommon chest wall tumor] |language=French |journal=Rev Mal Respir |volume=27 |issue=9 |pages=1089–91 |year=2010 |month=November |pmid=21111282 |doi=10.1016/j.rmr.2010.09.017 |url=}}</ref>
*Used to be classified as ''[[hemangiopericytoma]]'' (AKA solitary fibrous tumour).


==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid21474507>{{cite journal |author=Edgecombe A, Peterson RA, Shamji FM, Commons S, Sekhon H, Gomes MM |title=Myopericytoma: a pleural-based spindle cell neoplasm off the beaten path |journal=Int. J. Surg. Pathol. |volume=19 |issue=2 |pages=247–51 |year=2011 |month=April |pmid=21474507 |doi=10.1177/1066896910381897 |url=}}</ref><ref name=Ref_WMSP615>{{Ref WMSP|615}}</ref>
*Abundant, branching thin-walled blood vessels.
*Fascicular pattern - may be subtle - with:
*Small bland epithelioid cells with moderate eosinophilic cytoplasm.
**Compressed blood vessels, often thin walled & branching.
**Unequally spaced cells (unlike glomus tumour).
**Increased peri-vascular cellularity.
*Cellular lesion:
**Small bland unequally spaced epithelioid/spindle cells.
**Moderate eosinophilic cytoplasm.


Notes:
Notes:
*Features overlap with [[myofibroma]].<ref name=pmid16394283>{{cite journal |author=Dray MS, McCarthy SW, Palmer AA, ''et al.'' |title=Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases |journal=J. Clin. Pathol. |volume=59 |issue=1 |pages=67–73 |year=2006 |month=January |pmid=16394283 |pmc=1860256 |doi=10.1136/jcp.2005.028704 |url=}}</ref>
*Features overlap with [[myofibroma]].<ref name=pmid16394283>{{cite journal |author=Dray MS, McCarthy SW, Palmer AA, ''et al.'' |title=Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases |journal=J. Clin. Pathol. |volume=59 |issue=1 |pages=67–73 |year=2006 |month=January |pmid=16394283 |pmc=1860256 |doi=10.1136/jcp.2005.028704 |url=}}</ref>


Images:
DDx:
*[http://commons.wikimedia.org/wiki/File:Myopericytoma_-_b_-_high_mag.jpg Myopericytoma - high mag. (WC)].
*[[Solitary fibrous tumour]].
*[http://commons.wikimedia.org/wiki/File:Myopericytoma_-_intermed_mag.jpg Myopericytoma - intermed. mag. (WC)].
*[[Vascular tumours]].
*[[Angioleiomyoma]].<ref name=pmid16330949>{{cite journal |author=Mentzel T, Dei Tos AP, Sapi Z, Kutzner H |title=Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases |journal=Am. J. Surg. Pathol. |volume=30 |issue=1 |pages=104–13 |year=2006 |month=January |pmid=16330949 |doi= |url=}}</ref>
 
===Images===
<gallery>
Image:Myopericytoma - low mag.jpg |  Myopericytoma - low mag.  (WC)
Image:Myopericytoma - intermed mag.jpg |  Myopericytoma - intermed. mag.  (WC)
Image:Myopericytoma - high mag.jpg |  Myopericytoma - high mag. (WC)
Image:Myopericytoma - b - high mag.jpg |  Myopericytoma - high mag. (WC)
Image:Myopericytoma - very high mag.jpg |  Myopericytoma - very high mag.  (WC)
</gallery>
 
==IHC==
Features:<ref name=Ref_WMSP615>{{Ref WMSP|615}}</ref><ref name=eihc_myo>URL: [http://e-immunohistochemistry.info/web/Myopericytoma.htm http://e-immunohistochemistry.info/web/Myopericytoma.htm]. Accessed on: 6 May 2011.</ref>
*SMA +ve.
*H-caldesmon +ve.
*CD34 +ve (focal).
 
Others:<ref name=eihc_myo>URL: [http://e-immunohistochemistry.info/web/Myopericytoma.htm http://e-immunohistochemistry.info/web/Myopericytoma.htm]. Accessed on: 6 May 2011.</ref>
*AE1/AE3 -ve.
*EMA -ve.
 
==See also==
*[[Glomus tumour]] - the other perivascular tumour.
*[[Soft tissue lesions]].


==References==
==References==

Latest revision as of 05:27, 26 October 2015

Myopericytoma, also glomangiopericytoma, is a rare perivascular soft tissue tumour.

Myopericytoma
Diagnosis in short

Myopericytoma. H&E stain.
LM fascicular pattern (may be subtle) with compressed blood vessels (often thin walled & branching), increased peri-vascular cellularity; high cellularity; small bland unequally spaced epithelioid/spindle cells with moderate eosinophilic cytoplasm
LM DDx solitary fibrous tumour, vascular tumours
IHC SMA +ve, H-caldesmon +ve, CD34 +ve (focal), EMA -ve, AE1/AE3 -ve
Site soft tissue
Prevalence uncommon
Prognosis benign

General

  • Usually benign.
  • Typically in the distal extremities.[1]
  • Used to be classified as hemangiopericytoma (AKA solitary fibrous tumour).

Microscopic

Features:[2][3]

  • Fascicular pattern - may be subtle - with:
    • Compressed blood vessels, often thin walled & branching.
    • Increased peri-vascular cellularity.
  • Cellular lesion:
    • Small bland unequally spaced epithelioid/spindle cells.
    • Moderate eosinophilic cytoplasm.

Notes:

DDx:

Images

  • Myopericytoma - low mag. (WC)

  • Myopericytoma - intermed. mag. (WC)

  • Myopericytoma - high mag. (WC)

  • Myopericytoma - high mag. (WC)

  • Myopericytoma - very high mag. (WC)

IHC

Features:[3][6]

  • SMA +ve.
  • H-caldesmon +ve.
  • CD34 +ve (focal).

Others:[6]

  • AE1/AE3 -ve.
  • EMA -ve.

See also

References

  1. ↑ Zidane A, Arsalane A, Harkat A, et al. (November 2010). "[Myopericytoma: an uncommon chest wall tumor]" (in French). Rev Mal Respir 27 (9): 1089–91. doi:10.1016/j.rmr.2010.09.017. PMID 21111282.
  2. ↑ Edgecombe A, Peterson RA, Shamji FM, Commons S, Sekhon H, Gomes MM (April 2011). "Myopericytoma: a pleural-based spindle cell neoplasm off the beaten path". Int. J. Surg. Pathol. 19 (2): 247–51. doi:10.1177/1066896910381897. PMID 21474507.
  3. ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 615. ISBN 978-0781765275.
  4. ↑ Dray MS, McCarthy SW, Palmer AA, et al. (January 2006). "Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases". J. Clin. Pathol. 59 (1): 67–73. doi:10.1136/jcp.2005.028704. PMC 1860256. PMID 16394283. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860256/.
  5. ↑ Mentzel T, Dei Tos AP, Sapi Z, Kutzner H (January 2006). "Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases". Am. J. Surg. Pathol. 30 (1): 104–13. PMID 16330949.
  6. ↑ 6.0 6.1 URL: http://e-immunohistochemistry.info/web/Myopericytoma.htm. Accessed on: 6 May 2011.
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