Difference between revisions of "Myopericytoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Myopericytoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Myopericytoma. [[H&E stain]]. | |||
| Micro = fascicular pattern (may be subtle) with compressed blood vessels (often thin walled & branching), increased peri-vascular cellularity; high cellularity; small bland unequally spaced epithelioid/spindle cells with moderate eosinophilic cytoplasm | |||
| Subtypes = | |||
| LMDDx = [[solitary fibrous tumour]], [[vascular tumours]] | |||
| Stains = | |||
| IHC = SMA +ve, H-caldesmon +ve, CD34 +ve (focal), EMA -ve, AE1/AE3 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[soft tissue]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Myopericytoma''', also '''glomangiopericytoma''', is a rare perivascular [[soft tissue lesions|soft tissue tumour]]. | '''Myopericytoma''', also '''glomangiopericytoma''', is a rare perivascular [[soft tissue lesions|soft tissue tumour]]. | ||
==General== | ==General== | ||
* | *Usually benign. | ||
*Typically in the distal extremities.<ref name=pmid21111282>{{cite journal |author=Zidane A, Arsalane A, Harkat A, ''et al.'' |title=[Myopericytoma: an uncommon chest wall tumor] |language=French |journal=Rev Mal Respir |volume=27 |issue=9 |pages=1089–91 |year=2010 |month=November |pmid=21111282 |doi=10.1016/j.rmr.2010.09.017 |url=}}</ref> | *Typically in the distal extremities.<ref name=pmid21111282>{{cite journal |author=Zidane A, Arsalane A, Harkat A, ''et al.'' |title=[Myopericytoma: an uncommon chest wall tumor] |language=French |journal=Rev Mal Respir |volume=27 |issue=9 |pages=1089–91 |year=2010 |month=November |pmid=21111282 |doi=10.1016/j.rmr.2010.09.017 |url=}}</ref> | ||
*Used to be classified as ''[[hemangiopericytoma]]'' (AKA solitary fibrous tumour). | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid21474507>{{cite journal |author=Edgecombe A, Peterson RA, Shamji FM, Commons S, Sekhon H, Gomes MM |title=Myopericytoma: a pleural-based spindle cell neoplasm off the beaten path |journal=Int. J. Surg. Pathol. |volume=19 |issue=2 |pages=247–51 |year=2011 |month=April |pmid=21474507 |doi=10.1177/1066896910381897 |url=}}</ref><ref name=Ref_WMSP615>{{Ref WMSP|615}}</ref> | ||
* | *Fascicular pattern - may be subtle - with: | ||
*Small bland epithelioid cells | **Compressed blood vessels, often thin walled & branching. | ||
** | **Increased peri-vascular cellularity. | ||
*Cellular lesion: | |||
**Small bland unequally spaced epithelioid/spindle cells. | |||
**Moderate eosinophilic cytoplasm. | |||
Notes: | Notes: | ||
*Features overlap with [[myofibroma]].<ref name=pmid16394283>{{cite journal |author=Dray MS, McCarthy SW, Palmer AA, ''et al.'' |title=Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases |journal=J. Clin. Pathol. |volume=59 |issue=1 |pages=67–73 |year=2006 |month=January |pmid=16394283 |pmc=1860256 |doi=10.1136/jcp.2005.028704 |url=}}</ref> | *Features overlap with [[myofibroma]].<ref name=pmid16394283>{{cite journal |author=Dray MS, McCarthy SW, Palmer AA, ''et al.'' |title=Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases |journal=J. Clin. Pathol. |volume=59 |issue=1 |pages=67–73 |year=2006 |month=January |pmid=16394283 |pmc=1860256 |doi=10.1136/jcp.2005.028704 |url=}}</ref> | ||
DDx: | |||
*[ | *[[Solitary fibrous tumour]]. | ||
*[http:// | *[[Vascular tumours]]. | ||
*[[Angioleiomyoma]].<ref name=pmid16330949>{{cite journal |author=Mentzel T, Dei Tos AP, Sapi Z, Kutzner H |title=Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases |journal=Am. J. Surg. Pathol. |volume=30 |issue=1 |pages=104–13 |year=2006 |month=January |pmid=16330949 |doi= |url=}}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Myopericytoma - low mag.jpg | Myopericytoma - low mag. (WC) | |||
Image:Myopericytoma - intermed mag.jpg | Myopericytoma - intermed. mag. (WC) | |||
Image:Myopericytoma - high mag.jpg | Myopericytoma - high mag. (WC) | |||
Image:Myopericytoma - b - high mag.jpg | Myopericytoma - high mag. (WC) | |||
Image:Myopericytoma - very high mag.jpg | Myopericytoma - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=Ref_WMSP615>{{Ref WMSP|615}}</ref><ref name=eihc_myo>URL: [http://e-immunohistochemistry.info/web/Myopericytoma.htm http://e-immunohistochemistry.info/web/Myopericytoma.htm]. Accessed on: 6 May 2011.</ref> | |||
*SMA +ve. | |||
*H-caldesmon +ve. | |||
*CD34 +ve (focal). | |||
Others:<ref name=eihc_myo>URL: [http://e-immunohistochemistry.info/web/Myopericytoma.htm http://e-immunohistochemistry.info/web/Myopericytoma.htm]. Accessed on: 6 May 2011.</ref> | |||
*AE1/AE3 -ve. | |||
*EMA -ve. | |||
==See also== | |||
*[[Glomus tumour]] - the other perivascular tumour. | |||
*[[Soft tissue lesions]]. | |||
==References== | ==References== |
Latest revision as of 05:27, 26 October 2015
Myopericytoma | |
---|---|
Diagnosis in short | |
Myopericytoma. H&E stain. | |
| |
LM | fascicular pattern (may be subtle) with compressed blood vessels (often thin walled & branching), increased peri-vascular cellularity; high cellularity; small bland unequally spaced epithelioid/spindle cells with moderate eosinophilic cytoplasm |
LM DDx | solitary fibrous tumour, vascular tumours |
IHC | SMA +ve, H-caldesmon +ve, CD34 +ve (focal), EMA -ve, AE1/AE3 -ve |
Site | soft tissue |
| |
Prevalence | uncommon |
Prognosis | benign |
Myopericytoma, also glomangiopericytoma, is a rare perivascular soft tissue tumour.
General
- Usually benign.
- Typically in the distal extremities.[1]
- Used to be classified as hemangiopericytoma (AKA solitary fibrous tumour).
Microscopic
- Fascicular pattern - may be subtle - with:
- Compressed blood vessels, often thin walled & branching.
- Increased peri-vascular cellularity.
- Cellular lesion:
- Small bland unequally spaced epithelioid/spindle cells.
- Moderate eosinophilic cytoplasm.
Notes:
- Features overlap with myofibroma.[4]
DDx:
Images
IHC
- SMA +ve.
- H-caldesmon +ve.
- CD34 +ve (focal).
Others:[6]
- AE1/AE3 -ve.
- EMA -ve.
See also
- Glomus tumour - the other perivascular tumour.
- Soft tissue lesions.
References
- ↑ Zidane A, Arsalane A, Harkat A, et al. (November 2010). "[Myopericytoma: an uncommon chest wall tumor]" (in French). Rev Mal Respir 27 (9): 1089–91. doi:10.1016/j.rmr.2010.09.017. PMID 21111282.
- ↑ Edgecombe A, Peterson RA, Shamji FM, Commons S, Sekhon H, Gomes MM (April 2011). "Myopericytoma: a pleural-based spindle cell neoplasm off the beaten path". Int. J. Surg. Pathol. 19 (2): 247–51. doi:10.1177/1066896910381897. PMID 21474507.
- ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 615. ISBN 978-0781765275.
- ↑ Dray MS, McCarthy SW, Palmer AA, et al. (January 2006). "Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases". J. Clin. Pathol. 59 (1): 67–73. doi:10.1136/jcp.2005.028704. PMC 1860256. PMID 16394283. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860256/.
- ↑ Mentzel T, Dei Tos AP, Sapi Z, Kutzner H (January 2006). "Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases". Am. J. Surg. Pathol. 30 (1): 104–13. PMID 16330949.
- ↑ 6.0 6.1 URL: http://e-immunohistochemistry.info/web/Myopericytoma.htm. Accessed on: 6 May 2011.